HitPredict

Interactor 1: VAPB (O95292)
Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C)
Gene: VAPB

Interactor 2: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	26496610, 35384245, 24189400
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0046982 - protein heterodimerization activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 243 Hs			1 1255
+	Hs
		384008 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		ERBB2_HUMAN (1-1255): 0: 1282: 100.00
+	Hs
		310454 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		339063 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		310505 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		ERBB3_HUMAN (5-1254): 0: 1041: 38.55
+	Hs
		602015 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		ERBB3_HUMAN (5-1254): 0: 1041: 38.55
+	Hs
		310470 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		RET_HUMAN (426-1088): 3.53e-131: 432: 23.33
+	Hs
		434298 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		RET_HUMAN (426-1088): 3.53e-131: 432: 23.33
+	Hs
		169155 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		MUSK_HUMAN (486-984): 6.15e-120: 395: 25.14
+	Hs
		169211 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		MUSK_HUMAN (486-984): 6.15e-120: 395: 25.14
+	At
		1340129 VAP21_ARATH (3-242): 2.14e-60: 191: 24.90		Q9ZQC2_ARATH (372-1034): 9.27e-137: 443: 15.47
+	At
		84289 VAP21_ARATH (3-242): 2.14e-60: 191: 24.90		C0LGM1_ARATH (372-1034): 1.54e-136: 441: 15.27
+	Hs
		310468 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19
+	Hs
		411513 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19
+	Hs
		434244 MSPD2_HUMAN (4-182): 2.15e-38: 141: 25.41		RET_HUMAN (426-1088): 3.53e-131: 432: 23.33
+	Hs
		310571 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		EPHA5_HUMAN (707-1010): 2.37e-53: 206: 37.46
+	Hs
		310471 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		IGF1R_HUMAN (337-633): 4.59e-20: 99.1: 22.92
+	Hs
		310490 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		INSRR_HUMAN (359-644): 8.09e-16: 85.2: 19.27
+	Hs
		435786 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		IGF1R_HUMAN (337-633): 4.59e-20: 99.1: 22.92