HitPredict

Interactor 1: VAPB (O95292)
Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C)
Gene: VAPB

Interactor 2: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	25921289, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0042803 - protein homodimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 243 Hs			1 796
+	Hs
		385634 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		NTRK1_HUMAN (1-796): 0: 621: 100.00
+	Hs
		310482 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		FGFR1_HUMAN (195-794): 0: 545: 26.34
+	Hs
		310655 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72
+	Hs
		310653 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37
+	Hs
		310508 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		FGFR3_HUMAN (168-794): 3.98e-158: 481: 25.98
+	Hs
		310470 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		RET_HUMAN (391-794): 3.5e-114: 374: 30.44
+	Hs
		310517 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		EPHA3_HUMAN (262-788): 8.75e-112: 365: 26.64
+	Hs
		310571 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		EPHA5_HUMAN (409-788): 2.48e-111: 365: 30.36
+	Hs
		434298 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		RET_HUMAN (391-794): 3.5e-114: 374: 30.44
+	Hs
		310605 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		ROR1_HUMAN (515-783): 1.16e-72: 257: 46.89
+	Hs
		310471 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61
+	Hs
		310658 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		DDR2_HUMAN (499-781): 3.37e-72: 254: 44.55
+	Hs
		310468 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		INSR_HUMAN (493-777): 3e-68: 248: 42.62
+	Hs
		310490 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		INSRR_HUMAN (493-782): 6.64e-66: 241: 42.91
+	Hs
		310606 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		ROR2_HUMAN (515-783): 2.79e-66: 239: 43.91
+	Hs
		435786 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61
+	Hs
		310863 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		ALK_HUMAN (505-790): 8.72e-63: 231: 42.07
+	Hs
		411513 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		INSR_HUMAN (493-777): 3e-68: 248: 42.62
+	Hs
		169155 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		MUSK_HUMAN (171-374): 2.86e-13: 75.8: 18.61
+	Hs
		169211 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		MUSK_HUMAN (171-374): 2.86e-13: 75.8: 18.61