HitPredict

Interactor 1: VAPB (O95292)
Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C)
Gene: VAPB

Interactor 2: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 243 Hs			1 1114
+	Hs
		434298 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		RET_HUMAN (1-1114): 0: 1295: 100.00
+	At
		84920 VAP21_ARATH (3-242): 2.14e-60: 191: 24.90		Y5169_ARATH (227-1029): 0: 555: 13.87
+	Hs
		310482 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61
+	At
		84530 VAP21_ARATH (3-242): 2.14e-60: 191: 24.90		Y4245_ARATH (193-1037): 2.51e-175: 539: 12.47
+	At
		1340129 VAP21_ARATH (3-242): 2.14e-60: 191: 24.90		Q9ZQC2_ARATH (227-1062): 7.58e-173: 535: 13.91
+	Hs
		310508 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16
+	Hs
		310454 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24
+	Hs
		310461 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93
+	At
		84289 VAP21_ARATH (3-242): 2.14e-60: 191: 24.90		C0LGM1_ARATH (227-1062): 9.98e-169: 523: 13.78
+	Hs
		508237 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61
+	Hs
		310462 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69
+	Hs
		339063 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24
+	Hs
		384008 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93
+	Hs
		169155 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		MUSK_HUMAN (396-1018): 1.21e-135: 434: 25.28
+	Hs
		385634 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69
+	Hs
		169211 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		MUSK_HUMAN (396-1018): 1.21e-135: 434: 25.28
+	Hs
		310655 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		NTRK2_HUMAN (590-1018): 1.26e-124: 403: 30.74
+	Hs
		310653 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		NTRK3_HUMAN (638-1020): 2.11e-106: 355: 31.19
+	Hs
		1081631 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		NTRK3_HUMAN (638-1020): 2.11e-106: 355: 31.19
+	Hs
		310529 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		VGFR3_HUMAN (677-1012): 1.84e-76: 278: 41.25