HitPredict

Interactor 1: VAPB (O95292)
Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C)
Gene: VAPB

Interactor 2: ROS1 (P08922)
Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase)
Gene: ROS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 243 Hs			1 2347
+	Hs
		445881 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		ROS1_HUMAN (1-2347): 0: 2848: 100.00
+	Hs
		310517 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		EPHA3_HUMAN (1383-2242): 0: 590: 20.98
+	Hs
		310571 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		EPHA5_HUMAN (1360-2290): 0: 586: 19.28
+	Hs
		665437 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		EPHA3_HUMAN (1383-2242): 0: 590: 20.98
+	Hs
		310518 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		EPHA8_HUMAN (1383-2242): 1.9e-173: 562: 18.61
+	Hs
		310468 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		INSR_HUMAN (1424-2308): 7.33e-167: 555: 23.13
+	Hs
		665538 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		EPHA8_HUMAN (1383-2242): 1.9e-173: 562: 18.61
+	Hs
		310471 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		IGF1R_HUMAN (1442-2307): 3.63e-161: 538: 23.25
+	Hs
		310490 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		INSRR_HUMAN (1472-2261): 4.5e-161: 536: 24.97
+	Hs
		411513 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		INSR_HUMAN (1424-2308): 7.33e-167: 555: 23.13
+	Hs
		435786 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		IGF1R_HUMAN (1442-2307): 3.63e-161: 538: 23.25
+	Hs
		310520 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		UFO_HUMAN (1633-2297): 6.04e-130: 434: 25.83
+	Hs
		310863 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		ALK_HUMAN (1858-2311): 4.31e-84: 309: 38.96
+	Hs
		310470 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		RET_HUMAN (1940-2216): 6.4e-64: 241: 42.76
+	Hs
		310508 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		FGFR3_HUMAN (1886-2215): 4.22e-59: 222: 38.73
+	Hs
		434298 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		RET_HUMAN (1940-2216): 6.4e-64: 241: 42.76
+	Hs
		434244 MSPD2_HUMAN (4-182): 2.15e-38: 141: 25.41		RET_HUMAN (1940-2216): 6.4e-64: 241: 42.76