HitPredict

Interactor 1: VAPB (O95292)
Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C)
Gene: VAPB

Interactor 2: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	32877691
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005783 - endoplasmic reticulum GO:0019899 - enzyme binding GO:0030968 - endoplasmic reticulum unfolded protein response GO:0036498 - IRE1-mediated unfolded protein response and 1 others more... GO:0045296 - cadherin binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 243 Hs			1 435
+	Hs
		573951 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		PTN1_HUMAN (1-435): 0: 539: 100.00
+	Hs
		573810 MSPD2_HUMAN (4-182): 2.15e-38: 141: 25.41		PTN1_HUMAN (1-435): 0: 539: 100.00
+	Hs
		310611 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		PTN12_HUMAN (24-314): 1e-122: 376: 33.55
+	Hs
		983521 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		PTN12_HUMAN (24-314): 1e-122: 376: 33.55
+	Hs
		570557 MSPD2_HUMAN (4-182): 2.15e-38: 141: 25.41		PTN2_HUMAN (3-435): 3.97e-156: 449: 52.98