HitPredict

Interactor 1: VAPB (O95292)
Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C)
Gene: VAPB

Interactor 2: STX3 (Q13277)
Syntaxin-3
Gene: STX3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 243 Hs			1 289
+	Mm
		898821 Q8BH80_MOUSE (1-243): 1.1e-89: 266: 90.12		STX1B_MOUSE (1-288): 3.94e-79: 243: 59.79
+	Mm
		192853 Q8BH80_MOUSE (1-243): 1.1e-89: 266: 90.12		STX1A_MOUSE (1-287): 5.47e-77: 237: 63.45
+	Hs
		310582 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		STX1B_HUMAN (1-288): 3.94e-79: 243: 59.79
+	Hs
		310524 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		STX2_HUMAN (1-287): 3.91e-77: 238: 63.45
+	Hs
		310656 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		STX1A_HUMAN (1-286): 4.49e-75: 233: 62.98
+	Hs
		1084002 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		STX1A_HUMAN (1-286): 4.49e-75: 233: 62.98
+	Hs
		310616 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		STX4_HUMAN (1-286): 8.41e-62: 199: 39.32
+	Hs
		1017830 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		STX4_HUMAN (1-286): 8.41e-62: 199: 39.32
+	Hs
		178343 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		STX7_HUMAN (37-284): 2.99e-48: 163: 25.79
+	Hs
		178823 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		STX7_HUMAN (37-284): 2.99e-48: 163: 25.79
+	At
		1258324 VAP11_ARATH (3-194): 1.3e-60: 193: 25.71		SY132_ARATH (7-265): 1.87e-48: 164: 23.25
+	At
		1258341 VAP11_ARATH (3-194): 1.3e-60: 193: 25.71		SYP31_ARATH (2-283): 3.98e-47: 162: 14.58
+	At
		1258069 VAP42_ARATH (8-186): 5.77e-48: 161: 20.65		SYP42_ARATH (37-283): 2.41e-55: 183: 20.57
+	At
		1258071 VAP42_ARATH (8-186): 5.77e-48: 161: 20.65		SY121_ARATH (28-265): 1.04e-53: 179: 22.40
+	At
		1258067 VAP42_ARATH (8-186): 5.77e-48: 161: 20.65		SYP43_ARATH (34-283): 2.38e-50: 170: 17.90
+	At
		1258068 VAP42_ARATH (8-186): 5.77e-48: 161: 20.65		SY122_ARATH (27-265): 3.1e-50: 170: 24.70
+	At
		1258065 VAP42_ARATH (8-186): 5.77e-48: 161: 20.65		SY132_ARATH (7-265): 1.87e-48: 164: 23.25
+	At
		1258070 VAP42_ARATH (8-186): 5.77e-48: 161: 20.65		SY123_ARATH (15-266): 3.35e-48: 164: 28.03
+	At
		955669 VAP42_ARATH (8-186): 5.77e-48: 161: 20.65		SYP22_ARATH (40-271): 4.19e-47: 160: 19.67
+	At
		955662 VAP41_ARATH (11-186): 1.31e-44: 152: 21.43		SYP22_ARATH (40-271): 4.19e-47: 160: 19.67