HitPredict

Interactor 1: VAPB (O95292)
Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C)
Gene: VAPB

Interactor 2: ESYT1 (Q9BSJ8)
Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein)
Gene: ESYT1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35271311, 37931956
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0061817 - endoplasmic reticulum-plasma membrane tethering
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 243 Hs			1 1104
+	Hs
		1311435 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		ESYT1_HUMAN (1-1104): 0: 874: 100.00
+	Hs
		48214 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		ESYT2_HUMAN (848-1101): 9e-14: 78.1: 12.32
+	Hs
		48545 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		ESYT2_HUMAN (848-1101): 9e-14: 78.1: 12.32
+	Sc
		767965 SCS2_YEAST (8-221): 1.47e-36: 130: 22.03		TCB3_YEAST (242-773): 1.82e-20: 100: 13.25
+	Sc
		767992 SCS2_YEAST (8-221): 1.47e-36: 130: 22.03		TCB1_YEAST (328-478): 6.36e-18: 91.9: 16.77
+	Hs
		48429 MSPD2_HUMAN (4-182): 2.15e-38: 141: 25.41		ESYT2_HUMAN (848-1101): 9e-14: 78.1: 12.32