HitPredict

Interactor 1: VAPB (O95292)
Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C)
Gene: VAPB

Interactor 2: OSBL2 (Q9H1P3)
Oxysterol-binding protein-related protein 2 (ORP-2) (OSBP-related protein 2)
Gene: OSBPL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.730

Property	Details
Experiments	25416956, 26186194, 28514442, 33961781, 24885147, 31515488
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0030301 - cholesterol transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 243 Hs			1 480
+	Hs
		1122072 Q53XM7_HUMAN (1-243): 2.23e-87: 260: 100.00		OSBL2_HUMAN (1-480): 0: 601: 100.00
+	Hs
		1328794 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		OSBL2_HUMAN (1-480): 0: 601: 100.00
+	Hs
		310786 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		OSBL1_HUMAN (3-480): 0: 574: 64.52
+	Hs
		1315823 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		OSBL1_HUMAN (3-480): 0: 574: 64.52
+	Hs
		310745 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		OSBP2_HUMAN (1-480): 1.21e-168: 500: 34.80
+	Hs
		310813 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		OSBL3_HUMAN (2-470): 6.41e-166: 492: 36.95
+	Hs
		1282120 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		OSBP2_HUMAN (1-480): 1.21e-168: 500: 34.80
+	Hs
		310792 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		OSBL6_HUMAN (2-470): 3.81e-161: 481: 35.98
+	Hs
		310506 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		OSBP1_HUMAN (2-480): 4.47e-162: 480: 35.96
+	Hs
		1331232 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		OSBL3_HUMAN (2-470): 6.41e-166: 492: 36.95
+	Hs
		1318032 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		OSBL6_HUMAN (2-470): 3.81e-161: 481: 35.98
+	Hs
		603095 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		OSBP1_HUMAN (2-480): 4.47e-162: 480: 35.96
+	Hs
		1318024 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		OSBL7_HUMAN (2-469): 2.08e-154: 461: 34.31
+	Hs
		310768 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		OSBL9_HUMAN (2-471): 5.91e-130: 395: 20.75
+	Hs
		310785 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		OSB10_HUMAN (24-470): 1.92e-124: 382: 20.21
+	Hs
		1302540 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		OSBL9_HUMAN (2-471): 5.91e-130: 395: 20.75
+	Hs
		310791 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		OSBL8_HUMAN (9-479): 1.08e-120: 375: 23.43
+	Hs
		310784 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		OSB11_HUMAN (4-470): 4.14e-118: 365: 17.59
+	Hs
		1315200 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		OSB10_HUMAN (24-470): 1.92e-124: 382: 20.21
+	Hs
		1315187 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		OSB11_HUMAN (4-470): 4.14e-118: 365: 17.59