HitPredict

Interactor 1: VAPB (O95292)
Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C)
Gene: VAPB

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 243 Hs			1 1620
+	Hs
		310470 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		RET_HUMAN (842-1477): 4.8e-137: 455: 23.56
+	Hs
		434298 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		RET_HUMAN (842-1477): 4.8e-137: 455: 23.56
+	Hs
		310517 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		EPHA3_HUMAN (943-1427): 7.27e-120: 404: 25.87
+	Hs
		310508 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		FGFR3_HUMAN (952-1449): 6.42e-121: 401: 26.31
+	Hs
		310473 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		ROS1_HUMAN (1039-1461): 3.68e-112: 397: 37.75
+	Hs
		169155 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		MUSK_HUMAN (983-1391): 2.02e-118: 396: 29.98
+	Hs
		310482 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		FGFR1_HUMAN (952-1454): 2.04e-118: 395: 26.06
+	Hs
		310468 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		INSR_HUMAN (973-1436): 1.01e-112: 392: 34.25
+	Hs
		310471 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Hs
		665437 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		EPHA3_HUMAN (943-1427): 7.27e-120: 404: 25.87
+	Hs
		445881 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		ROS1_HUMAN (1039-1461): 3.68e-112: 397: 37.75
+	Hs
		169211 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		MUSK_HUMAN (983-1391): 2.02e-118: 396: 29.98
+	Hs
		508237 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		FGFR1_HUMAN (952-1454): 2.04e-118: 395: 26.06
+	Hs
		411513 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		INSR_HUMAN (973-1436): 1.01e-112: 392: 34.25
+	Hs
		435786 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Hs
		310490 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		INSRR_HUMAN (1082-1384): 2.38e-70: 262: 43.46
+	Hs
		310655 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		NTRK2_HUMAN (1093-1375): 7.35e-64: 236: 41.44
+	Hs
		310462 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		310653 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		NTRK3_HUMAN (1093-1375): 2.69e-59: 223: 39.03
+	Hs
		385634 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07