HitPredict

Interactor 1: VAPB (O95292)
Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C)
Gene: VAPB

Interactor 2: TMED5 (Q9Y3A6)
Transmembrane emp24 domain-containing protein 5 (p24 family protein gamma-2) (p24gamma2) (p28)
Gene: TMED5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0005794 - Golgi apparatus GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 243 Hs			1 229
+	Hs
		1349661 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		TMED5_HUMAN (1-229): 2.95e-77: 233: 100.00
+	Hs
		310645 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		TMED2_HUMAN (34-225): 2.01e-60: 190: 24.87
+	Hs
		1313971 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		TMED9_HUMAN (1-225): 2.45e-60: 191: 21.52
+	Hs
		1071854 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		TMED2_HUMAN (34-225): 2.01e-60: 190: 24.87
+	Hs
		1034815 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		TMED1_HUMAN (17-229): 7.15e-59: 187: 57.01
+	Hs
		310553 VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00		TMEDA_HUMAN (33-225): 1.35e-50: 165: 17.59
+	Hs
		833362 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		TMEDA_HUMAN (33-225): 1.35e-50: 165: 17.59
+	Sc
		698418 SCS2_YEAST (8-221): 1.47e-36: 130: 22.03		EMP24_YEAST (33-225): 6.66e-33: 119: 23.50