HitPredict

Interactor 1: SIX3 (O95343)
Homeobox protein SIX3 (Sine oculis homeobox homolog 3)
Gene: SIX3

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	0.60	0.527

Property	Details
Experiments	12441302
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005667 - transcription regulator complex GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 332 Hs			1 197
+	Mm
		1143691 SIX3_MOUSE (1-332): 2.36e-120: 351: 96.70		TLE4_MOUSE (2-191): 3.77e-112: 338: 68.59
+	Hs
		311439 SIX3_HUMAN (1-332): 2.29e-121: 353: 100.00		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Mm
		925828 SIX3_MOUSE (1-332): 2.36e-120: 351: 96.70		TLE5_MOUSE (1-197): 2.66e-101: 292: 99.49
+	Hs
		315171 SIX6_HUMAN (79-332): 7.73e-93: 278: 77.56		TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59
+	Hs
		315169 SIX6_HUMAN (79-332): 7.73e-93: 278: 77.56		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Mm
		1143964 SIX6_MOUSE (79-332): 8.54e-91: 272: 75.98		TLE4_MOUSE (2-191): 3.77e-112: 338: 68.59
+	Hs
		980654 SIX2_HUMAN (79-305): 5.29e-89: 270: 60.79		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		315170 SIX6_HUMAN (79-332): 7.73e-93: 278: 77.56		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		980756 SIX1_HUMAN (79-327): 1.48e-90: 273: 55.34		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		980881 SIX2_HUMAN (79-305): 5.29e-89: 270: 60.79		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		315172 SIX6_HUMAN (79-332): 7.73e-93: 278: 77.56		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		993432 SIX1_HUMAN (79-327): 1.48e-90: 273: 55.34		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Mm
		925832 SIX6_MOUSE (79-332): 8.54e-91: 272: 75.98		TLE5_MOUSE (1-197): 2.66e-101: 292: 99.49
+	Hs
		993614 SIX2_HUMAN (79-305): 5.29e-89: 270: 60.79		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		1132994 SIX2_HUMAN (79-305): 5.29e-89: 270: 60.79		Q5T3G3_HUMAN (2-197): 1.07e-99: 290: 61.43
+	Dm
		558378 SO_DROME (82-322): 1.16e-80: 252: 50.62		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		558386 OPTIX_DROME (52-329): 3.49e-77: 246: 57.50		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Hs
		993567 MEIS3_HUMAN (208-307): 5.27e-29: 116: 32.69		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Ce
		137686 HM32_CAEEL (46-329): 5.65e-75: 239: 45.78		UNC37_CAEEL (18-160): 8.43e-43: 153: 28.47