HitPredict

Interactor 1: SIX3 (O95343)
Homeobox protein SIX3 (Sine oculis homeobox homolog 3)
Gene: SIX3

Interactor 2: NR4A3 (Q92570)
Nuclear receptor subfamily 4 group A member 3 (Mitogen-induced nuclear orphan receptor) (Neuron-derived orphan receptor 1) (Nuclear hormone receptor NOR-1)
Gene: NR4A3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.77 0.60 0.681

The method score is based on:

Property Details
Experiments 12543801, 15523651, 11173923
Identification Methods pull down, affinity chromatography technology, two hybrid, gal4 vp16 complementation
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0005634 - nucleus
and 2 others

more...
Homologous interactions 8

Homologous interactions

Color coding for hit scores

1 332
Hs

1 626
+ Hs
+ Hs
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+ Mm
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024