HitPredict

Interactor 1: SMC2 (O95347)
Structural maintenance of chromosomes protein 2 (SMC protein 2) (SMC-2) (Chromosome-associated protein E) (hCAP-E) (XCAP-E homolog)
Gene: SMC2

Interactor 2: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	37827155, 21504906, 24332808
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003697 - single-stranded DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1197 Hs			1 616
+	Hs
		652371 SMC4_HUMAN (1-1176): 1.1e-87: 312: 17.32		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		651210 SMC1A_HUMAN (2-1181): 1.96e-73: 269: 17.18		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		652628 SMC3_HUMAN (1-1187): 2.82e-73: 268: 18.01		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Sc
		607361 SMC4_YEAST (1-1177): 4.88e-65: 244: 15.59		RFA1_YEAST (4-615): 0: 596: 31.69