HitPredict

Interactor 1: SMC2 (O95347)
Structural maintenance of chromosomes protein 2 (SMC protein 2) (SMC-2) (Chromosome-associated protein E) (hCAP-E) (XCAP-E homolog)
Gene: SMC2

Interactor 2: TIF1B (Q13263)
Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)
Gene: TRIM28

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29955894
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1197 Hs			1 835
+	Hs
		1029927 SMC4_HUMAN (1-1176): 1.1e-87: 312: 17.32		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		1030030 SMC3_HUMAN (1-1187): 2.82e-73: 268: 18.01		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		311646 SMC2_HUMAN (1-1197): 9.22e-128: 423: 100.00		TRI33_HUMAN (406-826): 1.6e-54: 206: 19.32
+	Hs
		1345726 SMC4_HUMAN (1-1176): 1.1e-87: 312: 17.32		TRI33_HUMAN (406-826): 1.6e-54: 206: 19.32
+	Hs
		1357683 SMC3_HUMAN (1-1187): 2.82e-73: 268: 18.01		TRI33_HUMAN (406-826): 1.6e-54: 206: 19.32
+	Hs
		170367 SMC1A_HUMAN (2-1181): 1.96e-73: 269: 17.18		TIF1A_HUMAN (404-808): 1.31e-52: 200: 21.55
+	Hs
		170514 SMC3_HUMAN (1-1187): 2.82e-73: 268: 18.01		TIF1A_HUMAN (404-808): 1.31e-52: 200: 21.55