HitPredict

Interactor 1: ATG7 (O95352)
Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7) (Autophagy-related protein 7) (APG7-like) (hAGP7) (Ubiquitin-activating enzyme E1-like protein)
Gene: ATG7

Interactor 2: GBRL1 (Q9H0R8)
Gamma-aminobutyric acid receptor-associated protein-like 1 (Early estrogen-regulated protein) (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1)
Gene: GABARAPL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.825

Property	Details
Experiments	20562859, 16704426
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	ATG8~ThiF
Common GO terms	GO:0000045 - autophagosome assembly GO:0005829 - cytosol GO:0006995 - cellular response to nitrogen starvation
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 703 Hs			1 117
+	Hs
		311683 ATG7_HUMAN (1-703): 0: 951: 100.00		GBRL2_HUMAN (1-116): 1.39e-57: 175: 61.21
+	Hs
		305873 ATG7_HUMAN (1-703): 0: 951: 100.00		GBRAP_HUMAN (1-116): 2.96e-56: 171: 87.07
+	Mm
		891376 ATG7_MOUSE (5-703): 0: 941: 92.99		GBRL2_MOUSE (1-116): 1.39e-57: 175: 61.21
+	Mm
		1322119 ATG7_MOUSE (5-703): 0: 941: 92.99		GBRAP_MOUSE (1-116): 2.96e-56: 171: 87.07
+	Hs
		311750 ATG7_HUMAN (1-703): 0: 951: 100.00		MLP3C_HUMAN (5-116): 1.61e-44: 143: 39.47
+	Hs
		311758 ATG7_HUMAN (1-703): 0: 951: 100.00		MLP3A_HUMAN (5-116): 1.09e-44: 142: 34.21
+	Hs
		311755 ATG7_HUMAN (1-703): 0: 951: 100.00		MLP3B_HUMAN (2-116): 1.06e-43: 140: 31.62
+	Mm
		1265088 ATG7_MOUSE (5-703): 0: 941: 92.99		MLP3A_MOUSE (5-116): 1.09e-44: 142: 34.21
+	Mm
		1321768 ATG7_MOUSE (5-703): 0: 941: 92.99		MLP3B_MOUSE (2-116): 3.03e-44: 141: 31.62
+	At
		1277811 ATG7_ARATH (13-691): 0: 780: 45.73		ATG8D_ARATH (3-116): 6.55e-62: 186: 56.14
+	At
		1258019 ATG7_ARATH (13-691): 0: 780: 45.73		ATG8F_ARATH (2-116): 7.47e-61: 183: 54.78
+	Dm
		1177993 Q7JY94_DROME (13-701): 0: 766: 40.17		Q9W2S2_DROME (1-116): 1.56e-57: 175: 85.35
+	Ce
		104029 G5EBK4_CAEEL (15-691): 0: 683: 40.12		LGG1_CAEEL (1-116): 3.74e-55: 169: 78.45
+	Sc
		745982 ATG7_YEAST (11-702): 0: 645: 37.14		ATG8_YEAST (1-117): 2.89e-59: 179: 54.70
+	Ce
		104032 G5EBK4_CAEEL (15-691): 0: 683: 40.12		LGG2_CAEEL (4-116): 6.14e-39: 128: 35.65
+	Dm
		55857 A1ZBA9_DROME (13-74): 1.08e-17: 88.7: 33.87		Q9W2S2_DROME (1-116): 1.56e-57: 175: 85.35