HitPredict

Interactor 1: ARI2 (O95376)
E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (EC 2.3.2.31) (RING-type E3 ubiquitin transferase ARIH2) (Triad1 protein)
Gene: ARIH2

Interactor 2: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	30587576, 19340006
Identification Methods	pull down, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ariadne~ubiquitin, IBR~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 493 Hs			1 685
+	Hs
		476630 ARI1_HUMAN (55-492): 4.1e-167: 485: 34.44		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476496 AKIB1_HUMAN (56-491): 2.19e-126: 396: 24.41		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475939 RN19B_HUMAN (122-354): 3.39e-73: 247: 22.49		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476460 RN216_HUMAN (12-352): 1.01e-71: 245: 16.39		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476187 RNF31_HUMAN (104-374): 5.18e-60: 215: 19.72		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475976 R144B_HUMAN (110-351): 4.01e-65: 214: 24.70		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475494 R144A_HUMAN (134-351): 1.18e-57: 194: 26.22		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		226335 PRKN_HUMAN (113-330): 7.77e-52: 184: 22.93		UBC_HUMAN (1-685): 0: 846: 100.00
+	Dm
		477528 LUBEL_DROME (6-371): 4.58e-75: 259: 18.25		UBIQP_DROME (1-610): 0: 752: 99.84
+	Dm
		1214032 LUBEL_DROME (6-371): 4.58e-75: 259: 18.25		Q9W418_DROME (229-685): 0: 557: 99.78
+	Sc
		477225 HEL1_YEAST (22-488): 3.89e-132: 395: 25.00		UBI4P_YEAST (381-685): 5e-122: 370: 95.74
+	Hs
		312457 ARI2_HUMAN (1-493): 0: 546: 100.00		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Hs
		475094 CUL9_HUMAN (64-465): 3.89e-125: 404: 25.37		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Mm
		476729 RN216_MOUSE (12-352): 5.16e-74: 251: 17.21		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		475069 RN19B_HUMAN (122-354): 3.39e-73: 247: 22.49		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Mm
		476959 RNF31_MOUSE (105-374): 1.14e-60: 216: 19.79		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		475133 RNF31_HUMAN (104-374): 5.18e-60: 215: 19.72		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Hs
		226251 PRKN_HUMAN (113-330): 7.77e-52: 184: 22.93		ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69
+	Hs
		171468 PRKN_HUMAN (113-330): 7.77e-52: 184: 22.93		UBD_HUMAN (155-304): 5.41e-28: 112: 32.05
+	Hs
		226334 PRKN_HUMAN (113-330): 7.77e-52: 184: 22.93		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70