HitPredict

Interactor 1: ARI2 (O95376)
E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (EC 2.3.2.31) (RING-type E3 ubiquitin transferase ARIH2) (Triad1 protein)
Gene: ARIH2

Interactor 2: NEDD8 (Q15843)
NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)
Gene: NEDD8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	30587576, 24076655
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ariadne~ubiquitin, IBR~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 493 Hs			1 81
+	Hs
		312457 ARI2_HUMAN (1-493): 0: 546: 100.00		UBB_HUMAN (1-76): 2.4e-30: 107: 57.90
+	Hs
		1079643 ARI1_HUMAN (55-492): 4.1e-167: 485: 34.44		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00
+	Hs
		475094 CUL9_HUMAN (64-465): 3.89e-125: 404: 25.37		UBB_HUMAN (1-76): 2.4e-30: 107: 57.90
+	Hs
		1079540 CUL9_HUMAN (64-465): 3.89e-125: 404: 25.37		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00
+	Hs
		475069 RN19B_HUMAN (122-354): 3.39e-73: 247: 22.49		UBB_HUMAN (1-76): 2.4e-30: 107: 57.90
+	Hs
		475133 RNF31_HUMAN (104-374): 5.18e-60: 215: 19.72		UBB_HUMAN (1-76): 2.4e-30: 107: 57.90
+	Hs
		227107 PRKN_HUMAN (113-330): 7.77e-52: 184: 22.93		RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14
+	Hs
		227108 PRKN_HUMAN (113-330): 7.77e-52: 184: 22.93		RL40_HUMAN (1-76): 3.79e-33: 112: 57.90
+	Hs
		226334 PRKN_HUMAN (113-330): 7.77e-52: 184: 22.93		UBB_HUMAN (1-76): 2.4e-30: 107: 57.90
+	Hs
		227560 PRKN_HUMAN (113-330): 7.77e-52: 184: 22.93		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00