HitPredict

Interactor 1: ARI2 (O95376)
E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (EC 2.3.2.31) (RING-type E3 ubiquitin transferase ARIH2) (Triad1 protein)
Gene: ARIH2

Interactor 2: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.83 1.00 0.914

The method score is based on:

Property Details
Experiments 30587576, 31253590, 33961781, 24076655
Identification Methods affinity chromatography technology, pull down, enzymatic study, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Ariadne~Cullin, Cullin_Nedd8~IBR
Common GO terms GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0016567 - protein ubiquitination
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 493
Hs

1 780
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024