HitPredict

Interactor 1: M3K6 (O95382)
Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2)
Gene: MAP3K6

Interactor 2: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	32707033, 19935702, 36931259
Identification Methods	affinity chromatography technology, pull down, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1288 Hs			1 248
+	Hs
		312790 M3K6_HUMAN (1-1288): 0: 1354: 99.38		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		312792 M3K6_HUMAN (1-1288): 0: 1354: 99.38		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		312777 M3K6_HUMAN (1-1288): 0: 1354: 99.38		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		312780 M3K6_HUMAN (1-1288): 0: 1354: 99.38		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		312789 M3K6_HUMAN (1-1288): 0: 1354: 99.38		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		312793 M3K6_HUMAN (1-1288): 0: 1354: 99.38		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Hs
		684290 M3K5_HUMAN (2-1282): 0: 1194: 44.40		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		909955 M3K5_HUMAN (2-1282): 0: 1194: 44.40		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		909709 M3K15_HUMAN (2-1278): 0: 1186: 43.56		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		927451 M3K5_HUMAN (2-1282): 0: 1194: 44.40		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		927194 M3K15_HUMAN (2-1278): 0: 1186: 43.56		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		647219 M3K5_HUMAN (2-1282): 0: 1194: 44.40		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		683661 M3K5_HUMAN (2-1282): 0: 1194: 44.40		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		905034 M3K5_HUMAN (2-1282): 0: 1194: 44.40		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		982422 M3K5_HUMAN (2-1282): 0: 1194: 44.40		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Hs
		982174 M3K15_HUMAN (2-1278): 0: 1186: 43.56		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Hs
		684157 MARK2_HUMAN (596-1261): 5.09e-129: 418: 14.12		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		159186 CSKP_HUMAN (648-1288): 4.4e-132: 430: 16.86		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		647041 MARK2_HUMAN (596-1261): 5.09e-129: 418: 14.12		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		683485 MARK2_HUMAN (596-1261): 5.09e-129: 418: 14.12		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62