HitPredict

Interactor 1: M3K6 (O95382)
Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2)
Gene: MAP3K6

Interactor 2: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	19935702, 36931259
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1288 Hs			1 255
+	Hs
		909955 M3K5_HUMAN (2-1282): 0: 1194: 44.40		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		909709 M3K15_HUMAN (2-1278): 0: 1186: 43.56		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		159186 CSKP_HUMAN (648-1288): 4.4e-132: 430: 16.86		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		909730 MARK2_HUMAN (596-1261): 5.09e-129: 418: 14.12		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Mm
		910234 MARK2_MOUSE (596-1250): 2.52e-126: 410: 14.71		1433E_MOUSE (1-255): 4.87e-154: 430: 100.00
+	Hs
		783970 KPCI_HUMAN (446-976): 1.46e-126: 405: 18.25		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		909590 KS6A2_HUMAN (644-1151): 6.06e-125: 405: 19.31		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	At
		788620 M3K2_ARATH (594-1223): 7.95e-122: 394: 23.11		14333_ARATH (1-253): 3.45e-147: 413: 74.12
+	At
		965360 CIPKC_ARATH (624-1044): 1.39e-111: 360: 20.14		14332_ARATH (4-255): 1.05e-147: 414: 74.41
+	At
		788672 CIPKC_ARATH (624-1044): 1.39e-111: 360: 20.14		14333_ARATH (1-253): 3.45e-147: 413: 74.12
+	At
		1280891 CIPKC_ARATH (624-1044): 1.39e-111: 360: 20.14		14337_ARATH (2-255): 7.73e-147: 412: 71.21
+	Hs
		200101 DAPK3_HUMAN (635-1068): 4.89e-99: 325: 23.59		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		909502 STK4_HUMAN (652-910): 4.81e-97: 321: 35.00		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		909512 STK3_HUMAN (623-910): 5.87e-97: 321: 32.18		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Sc
		419854 SNF1_YEAST (630-1078): 1.85e-111: 365: 19.65		BMH2_YEAST (4-242): 1.14e-134: 382: 77.08
+	Sc
		419824 SNF1_YEAST (630-1078): 1.85e-111: 365: 19.65		BMH1_YEAST (2-243): 2.43e-134: 381: 75.72
+	Hs
		625306 CDK2_HUMAN (652-908): 3.75e-96: 311: 30.18		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		909957 M3K3_HUMAN (653-907): 4.61e-42: 166: 42.11		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Sp
		660886 BYR2_SCHPO (653-906): 3.11e-42: 167: 39.18		RAD24_SCHPO (2-255): 7.25e-135: 382: 70.77
+	Sp
		660887 BYR2_SCHPO (653-906): 3.11e-42: 167: 39.18		RAD25_SCHPO (2-236): 1.03e-134: 382: 74.89