HitPredict

Interactor 1: RPGF3 (O95398)
Rap guanine nucleotide exchange factor 3 (Exchange factor directly activated by cAMP 1) (Exchange protein directly activated by cAMP 1) (EPAC 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP) (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI)
Gene: RAPGEF3

Interactor 2: RAP2A (P10114)
Ras-related protein Rap-2a (EC 3.6.5.2) (RbBP-30)
Gene: RAP2A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	10777494
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~RasGEF, Ras~RasGEF_N
Common GO terms	GO:0005886 - plasma membrane GO:0032486 - Rap protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 923 Hs			1 183
+	Hs
		313171 RPGF3_HUMAN (1-923): 0: 890: 100.00		RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75
+	Hs
		313169 RPGF3_HUMAN (1-923): 0: 890: 100.00		RAP1B_HUMAN (1-182): 4.24e-79: 234: 60.66
+	Dm
		51591 A1Z6P8_DROME (22-923): 0: 708: 38.30		O96692_DROME (1-177): 8.99e-77: 229: 69.66
+	Hs
		486041 RPGF6_HUMAN (87-923): 4.74e-142: 462: 17.35		RAP2A_HUMAN (1-183): 7.32e-82: 241: 100.00
+	Hs
		919653 RPGF6_HUMAN (87-923): 4.74e-142: 462: 17.35		RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75
+	Hs
		486045 RPGF5_HUMAN (368-923): 1.89e-131: 408: 36.14		RAP2A_HUMAN (1-183): 7.32e-82: 241: 100.00
+	Hs
		919657 RPGF5_HUMAN (368-923): 1.89e-131: 408: 36.14		RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75
+	Hs
		897996 RPGF2_HUMAN (41-923): 7.14e-113: 380: 17.71		RAP2B_HUMAN (1-182): 2.01e-82: 243: 91.21
+	Hs
		919687 RPGF2_HUMAN (41-923): 7.14e-113: 380: 17.71		RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75
+	Hs
		349519 RPGF6_HUMAN (87-923): 4.74e-142: 462: 17.35		RASH_HUMAN (1-180): 3.16e-48: 156: 46.49
+	Hs
		897981 GNDS_HUMAN (380-917): 1.35e-114: 374: 16.50		RAP2B_HUMAN (1-182): 2.01e-82: 243: 91.21
+	Hs
		486024 GNDS_HUMAN (380-917): 1.35e-114: 374: 16.50		RAP2A_HUMAN (1-183): 7.32e-82: 241: 100.00
+	Hs
		919618 GNDS_HUMAN (380-917): 1.35e-114: 374: 16.50		RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75
+	Hs
		897883 GNDS_HUMAN (380-917): 1.35e-114: 374: 16.50		RAP1B_HUMAN (1-182): 4.24e-79: 234: 60.66
+	Hs
		1021726 GNDS_HUMAN (380-917): 1.35e-114: 374: 16.50		RIT1_HUMAN (2-164): 5.65e-56: 177: 49.69
+	Hs
		1021728 GNDS_HUMAN (380-917): 1.35e-114: 374: 16.50		RIT2_HUMAN (2-164): 6.6e-54: 172: 47.85
+	Hs
		349754 RPGF2_HUMAN (41-923): 7.14e-113: 380: 17.71		RASH_HUMAN (1-180): 3.16e-48: 156: 46.49
+	Hs
		349279 GNDS_HUMAN (380-917): 1.35e-114: 374: 16.50		RASH_HUMAN (1-180): 3.16e-48: 156: 46.49
+	Mm
		976137 GNDS_MOUSE (380-917): 4.28e-115: 374: 18.03		RASH_MOUSE (1-180): 3.16e-48: 156: 46.49
+	Sc
		350755 CDC25_YEAST (470-906): 1.15e-87: 309: 14.96		RAS1_YEAST (1-162): 3.43e-48: 160: 51.85