HitPredict

Interactor 1: ZFYV9 (O95405)
Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation)
Gene: ZFYVE9

Interactor 2: RAB5A (P20339)
Ras-related protein Rab-5A (EC 3.6.5.2)
Gene: RAB5A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005769 - early endosome GO:0005829 - cytosol GO:0006897 - endocytosis GO:0031901 - early endosome membrane GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1425 Hs			1 215
+	Hs
		313514 ZFYV9_HUMAN (1-1425): 0: 1620: 100.00		RAB5C_HUMAN (1-215): 3.96e-85: 252: 86.57
+	Hs
		313523 ZFYV9_HUMAN (1-1425): 0: 1620: 100.00		RB11A_HUMAN (11-215): 7.77e-83: 247: 38.32
+	Hs
		592340 ZFY16_HUMAN (1-1424): 0: 1145: 30.54		RAB5A_HUMAN (1-215): 2.09e-88: 260: 100.00
+	Hs
		844588 ZFY16_HUMAN (1-1424): 0: 1145: 30.54		RAB5C_HUMAN (1-215): 3.96e-85: 252: 86.57
+	Hs
		914169 ZFY16_HUMAN (1-1424): 0: 1145: 30.54		RB11A_HUMAN (11-215): 7.77e-83: 247: 38.32
+	Hs
		592451 RUFY1_HUMAN (156-763): 1.92e-101: 342: 14.72		RAB5A_HUMAN (1-215): 2.09e-88: 260: 100.00
+	Hs
		844698 RUFY1_HUMAN (156-763): 1.92e-101: 342: 14.72		RAB5C_HUMAN (1-215): 3.96e-85: 252: 86.57
+	Hs
		914301 RUFY1_HUMAN (156-763): 1.92e-101: 342: 14.72		RB11A_HUMAN (11-215): 7.77e-83: 247: 38.32
+	Dm
		1186040 Q7PLP5_DROME (91-765): 5.55e-78: 283: 12.05		RAB5_DROME (6-213): 9.84e-98: 284: 75.00
+	Hs
		914405 MTMR4_HUMAN (177-779): 1.32e-77: 283: 16.67		RB11A_HUMAN (11-215): 7.77e-83: 247: 38.32
+	Hs
		592265 EEA1_HUMAN (2-758): 9.63e-69: 257: 12.42		RAB5A_HUMAN (1-215): 2.09e-88: 260: 100.00
+	Hs
		844532 EEA1_HUMAN (2-758): 9.63e-69: 257: 12.42		RAB5C_HUMAN (1-215): 3.96e-85: 252: 86.57
+	Hs
		895354 EEA1_HUMAN (2-758): 9.63e-69: 257: 12.42		RAB5B_HUMAN (1-215): 3.87e-85: 252: 81.86
+	Dm
		1358755 Q9W2M0_DROME (365-762): 5.8e-59: 217: 15.79		RAB5_DROME (6-213): 9.84e-98: 284: 75.00
+	Hs
		592550 ANFY1_HUMAN (222-758): 6.51e-50: 196: 12.77		RAB5A_HUMAN (1-215): 2.09e-88: 260: 100.00
+	Hs
		1067485 EEA1_HUMAN (2-758): 9.63e-69: 257: 12.42		RB22A_HUMAN (20-213): 4.32e-63: 196: 49.23
+	Hs
		1044476 EEA1_HUMAN (2-758): 9.63e-69: 257: 12.42		RAB31_HUMAN (18-213): 9.74e-61: 190: 45.92
+	Hs
		844611 WDFY3_HUMAN (442-769): 1.21e-47: 190: 16.86		RAB5C_HUMAN (1-215): 3.96e-85: 252: 86.57
+	Hs
		914203 WDFY3_HUMAN (442-769): 1.21e-47: 190: 16.86		RB11A_HUMAN (11-215): 7.77e-83: 247: 38.32
+	Mm
		1206850 EEA1_MOUSE (2-758): 7.05e-62: 235: 12.40		RAB31_MOUSE (18-213): 4.76e-59: 186: 46.94