HitPredict

Interactor 1: ZFYV9 (O95405)
Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation)
Gene: ZFYVE9

Interactor 2: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005769 - early endosome GO:0005829 - cytosol GO:0031901 - early endosome membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1425 Hs			1 822
+	Hs
		313505 ZFYV9_HUMAN (1-1425): 0: 1620: 100.00		FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68
+	Hs
		313492 ZFYV9_HUMAN (1-1425): 0: 1620: 100.00		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		313504 ZFYV9_HUMAN (1-1425): 0: 1620: 100.00		FGFR2_HUMAN (120-821): 4.81e-164: 498: 23.04
+	Hs
		313545 ZFYV9_HUMAN (1-1425): 0: 1620: 100.00		DDR2_HUMAN (491-807): 5.97e-75: 263: 43.40
+	Hs
		608024 ZFY16_HUMAN (1-1424): 0: 1145: 30.54		FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68
+	Hs
		508079 ZFY16_HUMAN (1-1424): 0: 1145: 30.54		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		601538 ZFY16_HUMAN (1-1424): 0: 1145: 30.54		FGFR2_HUMAN (120-821): 4.81e-164: 498: 23.04
+	Hs
		385389 RUFY1_HUMAN (156-763): 1.92e-101: 342: 14.72		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		665422 RUFY1_HUMAN (156-763): 1.92e-101: 342: 14.72		EPHA3_HUMAN (82-821): 1.09e-157: 486: 21.32
+	Hs
		609293 EEA1_HUMAN (2-758): 9.63e-69: 257: 12.42		FGFR3_HUMAN (128-822): 1.4e-170: 514: 24.45
+	Hs
		601507 MTMR3_HUMAN (196-777): 2.87e-71: 263: 13.18		FGFR2_HUMAN (120-821): 4.81e-164: 498: 23.04
+	Hs
		385054 RUFY3_HUMAN (138-584): 6.08e-63: 224: 11.45		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		159837 HGS_HUMAN (654-976): 7.98e-53: 202: 19.55		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		159864 HGS_HUMAN (654-976): 7.98e-53: 202: 19.55		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		435676 FGD5_HUMAN (151-872): 3.46e-92: 330: 14.82		IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95
+	Hs
		159848 HGS_HUMAN (654-976): 7.98e-53: 202: 19.55		RET_HUMAN (436-820): 1.09e-115: 379: 33.00
+	Hs
		435647 EEA1_HUMAN (2-758): 9.63e-69: 257: 12.42		IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95
+	Rn
		94275 F1LUA1_RAT (40-758): 1.09e-60: 231: 11.74		INSR_RAT (513-809): 7.79e-68: 247: 42.72
+	Rn
		88876 D4A1J6_RAT (222-758): 6.37e-55: 212: 12.60		INSR_RAT (513-809): 7.79e-68: 247: 42.72
+	Hs
		159843 HGS_HUMAN (654-976): 7.98e-53: 202: 19.55		INSR_HUMAN (513-809): 2.11e-70: 254: 43.38