HitPredict

Interactor 1: FMNL1 (O95466)
Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin)
Gene: FMNL1

Interactor 2: PROF1 (P07737)
Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I)
Gene: PFN1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	10958683
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005938 - cell cortex GO:0016020 - membrane GO:0031267 - small GTPase binding GO:0070062 - extracellular exosome
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1100 Hs			1 140
+	Hs
		314847 FMNL1_HUMAN (1-1100): 0: 849: 100.00		PROF2_HUMAN (1-140): 1.13e-74: 220: 61.43
+	Hs
		430307 FMNL2_HUMAN (1-1097): 0: 834: 57.31		PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00
+	Hs
		430404 FHOD1_HUMAN (185-1099): 1.49e-138: 449: 16.22		PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00
+	Hs
		715022 FHOD1_HUMAN (185-1099): 1.49e-138: 449: 16.22		PROF2_HUMAN (1-140): 1.13e-74: 220: 61.43
+	Hs
		430197 INF2_HUMAN (181-1063): 2.53e-120: 402: 20.27		PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00
+	Hs
		714970 INF2_HUMAN (181-1063): 2.53e-120: 402: 20.27		PROF2_HUMAN (1-140): 1.13e-74: 220: 61.43
+	Hs
		430356 FMN2_HUMAN (597-1044): 1.9e-93: 330: 21.90		PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00
+	Hs
		203199 SYNJ1_HUMAN (75-729): 2.75e-84: 302: 14.75		PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00
+	Hs
		243087 DIAP2_HUMAN (33-421): 7.15e-68: 250: 19.24		PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00
+	Hs
		430352 DIAP3_HUMAN (4-542): 2.32e-65: 243: 16.64		PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00
+	Hs
		237549 DIAP1_HUMAN (73-391): 1.76e-41: 168: 18.10		PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00
+	Hs
		237564 DIAP1_HUMAN (73-391): 1.76e-41: 168: 18.10		PROF2_HUMAN (1-140): 1.13e-74: 220: 61.43