HitPredict

Interactor 1: CBX6 (O95503)
Chromobox protein homolog 6
Gene: CBX6

Interactor 2: H14 (P10412)
Histone H1.4 (Histone H1b) (Histone H1s-4)
Gene: H1-4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	21282530
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000792 - heterochromatin GO:0005634 - nucleus
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 412 Hs			1 219
+	Hs
		315962 CBX6_HUMAN (1-393): 1.39e-116: 347: 100.00		H12_HUMAN (1-177): 2.5e-23: 94.7: 88.76
+	Hs
		315961 CBX6_HUMAN (1-393): 1.39e-116: 347: 100.00		H15_HUMAN (1-157): 6.98e-18: 80.9: 75.00
+	Hs
		316015 CBX6_HUMAN (1-393): 1.39e-116: 347: 100.00		H11_HUMAN (38-148): 9.7e-18: 80.1: 75.68
+	Hs
		489290 CBX8_HUMAN (1-393): 2.31e-76: 243: 30.82		H14_HUMAN (1-115): 2.94e-23: 94.7: 100.00
+	Hs
		559255 CBX8_HUMAN (1-393): 2.31e-76: 243: 30.82		H15_HUMAN (1-157): 6.98e-18: 80.9: 75.00
+	Mm
		794626 CBX5_MOUSE (11-106): 1.59e-27: 109: 29.17		H14_MOUSE (1-204): 5.71e-28: 107: 94.12
+	Hs
		123239 CBX4_HUMAN (1-362): 3.71e-34: 135: 23.28		H11_HUMAN (38-148): 9.7e-18: 80.1: 75.68
+	Mm
		794637 Q9DCC5_MOUSE (9-121): 1.26e-25: 104: 24.56		H14_MOUSE (1-204): 5.71e-28: 107: 94.12
+	Hs
		488936 CBX5_HUMAN (11-106): 3.1e-28: 111: 29.17		H14_HUMAN (1-115): 2.94e-23: 94.7: 100.00
+	Mm
		794619 CBX1_MOUSE (17-85): 6.16e-23: 97.1: 34.78		H14_MOUSE (1-204): 5.71e-28: 107: 94.12
+	Hs
		489023 CBX3_HUMAN (9-121): 1.26e-25: 104: 24.56		H14_HUMAN (1-115): 2.94e-23: 94.7: 100.00
+	Hs
		559009 CBX5_HUMAN (11-106): 3.1e-28: 111: 29.17		H15_HUMAN (1-157): 6.98e-18: 80.9: 75.00
+	Mm
		794648 CBX5_MOUSE (11-106): 1.59e-27: 109: 29.17		H11_MOUSE (1-121): 9.49e-17: 77.4: 69.92