HitPredict

Interactor 1: CBX6 (O95503)
Chromobox protein homolog 6
Gene: CBX6

Interactor 2: DNMT1 (P26358)
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)
Gene: DNMT1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	21282530
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Chromo~DNA_methylase
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 1616
+	Hs
		203628 SUV91_HUMAN (11-222): 8.35e-36: 137: 17.21		DNMT1_HUMAN (1-1616): 0: 1717: 100.00
+	Hs
		641165 CBX5_HUMAN (11-106): 3.1e-28: 111: 29.17		DNMT1_HUMAN (1-1616): 0: 1717: 100.00
+	Hs
		641207 CBX3_HUMAN (9-121): 1.26e-25: 104: 24.56		DNMT1_HUMAN (1-1616): 0: 1717: 100.00
+	Hs
		641192 CBX1_HUMAN (17-85): 6.16e-23: 97.1: 34.78		DNMT1_HUMAN (1-1616): 0: 1717: 100.00
+	Hs
		1304483 MPP8_HUMAN (6-339): 4.19e-48: 177: 14.91		DNM3A_HUMAN (1128-1326): 1.35e-36: 152: 17.87
+	Hs
		203801 SUV91_HUMAN (11-222): 8.35e-36: 137: 17.21		DNM3B_HUMAN (1130-1325): 2.44e-41: 167: 17.65
+	Hs
		123345 CBX4_HUMAN (1-362): 3.71e-34: 135: 23.28		SMC3_HUMAN (112-523): 4.15e-40: 164: 12.53
+	Hs
		203822 SUV91_HUMAN (11-222): 8.35e-36: 137: 17.21		DNM3A_HUMAN (1128-1326): 1.35e-36: 152: 17.87
+	Hs
		123351 CBX4_HUMAN (1-362): 3.71e-34: 135: 23.28		DNM3A_HUMAN (1128-1326): 1.35e-36: 152: 17.87
+	Dm
		399045 HP1_DROME (11-118): 1.69e-25: 104: 27.52		Q9VKB3_DROME (1139-1371): 3.2e-48: 178: 19.09
+	Hs
		800543 CBX5_HUMAN (11-106): 3.1e-28: 111: 29.17		DNM3B_HUMAN (1130-1325): 2.44e-41: 167: 17.65
+	Hs
		1027303 CBX3_HUMAN (9-121): 1.26e-25: 104: 24.56		DNM3B_HUMAN (1130-1325): 2.44e-41: 167: 17.65
+	Hs
		949904 CBX1_HUMAN (17-85): 6.16e-23: 97.1: 34.78		DNM3B_HUMAN (1130-1325): 2.44e-41: 167: 17.65
+	Hs
		800563 CBX5_HUMAN (11-106): 3.1e-28: 111: 29.17		DNM3A_HUMAN (1128-1326): 1.35e-36: 152: 17.87
+	Hs
		1027214 CBX3_HUMAN (9-121): 1.26e-25: 104: 24.56		MINT_HUMAN (5-706): 1.98e-35: 150: 12.71
+	Hs
		949925 CBX1_HUMAN (17-85): 6.16e-23: 97.1: 34.78		DNM3A_HUMAN (1128-1326): 1.35e-36: 152: 17.87
+	At
		1276954 LHP1_ARATH (4-260): 3.46e-33: 131: 21.79		CMT3_ARATH (656-924): 1.39e-21: 104: 13.82
+	Hs
		800421 CBX5_HUMAN (11-106): 3.1e-28: 111: 29.17		NIPBL_HUMAN (4-361): 1.81e-13: 78.5: 14.14
+	Hs
		1027054 CBX3_HUMAN (9-121): 1.26e-25: 104: 24.56		NIPBL_HUMAN (4-361): 1.81e-13: 78.5: 14.14
+	Hs
		949814 CBX1_HUMAN (17-85): 6.16e-23: 97.1: 34.78		NIPBL_HUMAN (4-361): 1.81e-13: 78.5: 14.14