HitPredict

Interactor 1: CBX6 (O95503)
Chromobox protein homolog 6
Gene: CBX6

Interactor 2: ERCC6 (Q03468)
DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB)
Gene: ERCC6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	21282530
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Chromo~SNF2-rel_dom
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 1493
+	Hs
		976500 MPP8_HUMAN (6-339): 4.19e-48: 177: 14.91		ERCC6_HUMAN (1-1493): 0: 1168: 100.00
+	Hs
		123241 CBX4_HUMAN (1-362): 3.71e-34: 135: 23.28		ERCC6_HUMAN (1-1493): 0: 1168: 100.00
+	Hs
		316054 CBX6_HUMAN (1-393): 1.39e-116: 347: 100.00		ER6L2_HUMAN (493-1303): 0: 651: 27.38
+	Hs
		123332 CBX4_HUMAN (1-362): 3.71e-34: 135: 23.28		CHD7_HUMAN (3-1479): 0: 774: 17.81
+	Hs
		203687 SUV91_HUMAN (11-222): 8.35e-36: 137: 17.21		CHD4_HUMAN (303-1439): 0: 766: 18.35
+	Hs
		123245 CBX4_HUMAN (1-362): 3.71e-34: 135: 23.28		CHD3_HUMAN (303-1446): 0: 759: 19.68
+	Hs
		1027145 CBX3_HUMAN (9-121): 1.26e-25: 104: 24.56		CHD5_HUMAN (300-1446): 0: 783: 19.15
+	Hs
		1027026 CBX3_HUMAN (9-121): 1.26e-25: 104: 24.56		CHD9_HUMAN (3-1492): 0: 774: 18.73
+	Hs
		800380 CBX5_HUMAN (11-106): 3.1e-28: 111: 29.17		CHD4_HUMAN (303-1439): 0: 766: 18.35
+	Hs
		1027001 CBX3_HUMAN (9-121): 1.26e-25: 104: 24.56		CHD4_HUMAN (303-1439): 0: 766: 18.35
+	Hs
		800360 CBX5_HUMAN (11-106): 3.1e-28: 111: 29.17		CHD3_HUMAN (303-1446): 0: 759: 19.68
+	Hs
		1018451 CBX3_HUMAN (9-121): 1.26e-25: 104: 24.56		CHD3_HUMAN (303-1446): 0: 759: 19.68
+	Hs
		847118 CDYL_HUMAN (2-275): 6.83e-44: 163: 17.08		SMCA4_HUMAN (228-1324): 0: 677: 19.90
+	Hs
		1027277 CBX3_HUMAN (9-121): 1.26e-25: 104: 24.56		CHD8_HUMAN (2-1474): 0: 725: 16.46
+	Hs
		658667 CBX3_HUMAN (9-121): 1.26e-25: 104: 24.56		SMCA1_HUMAN (369-1372): 0: 700: 20.58
+	Hs
		229384 CBX3_HUMAN (9-121): 1.26e-25: 104: 24.56		SMCA5_HUMAN (368-1383): 0: 698: 20.75
+	Hs
		800320 CBX5_HUMAN (11-106): 3.1e-28: 111: 29.17		SMCA4_HUMAN (228-1324): 0: 677: 19.90
+	Hs
		846954 CBX3_HUMAN (9-121): 1.26e-25: 104: 24.56		SMCA4_HUMAN (228-1324): 0: 677: 19.90
+	Hs
		800319 CBX5_HUMAN (11-106): 3.1e-28: 111: 29.17		SMCA2_HUMAN (228-1247): 0: 660: 19.72
+	Hs
		163601 CBX3_HUMAN (9-121): 1.26e-25: 104: 24.56		BTAF1_HUMAN (490-1019): 9.59e-80: 293: 35.50