HitPredict

Interactor 1: RPA1 (O95602)
DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (A190) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) (RNA polymerase I 194 kDa subunit) (RPA194)
Gene: POLR1A

Interactor 2: RPAB5 (P62875)
DNA-directed RNA polymerases I, II, and III subunit RPABC5 (RNA polymerases I, II, and III subunit ABC5) (DNA-directed RNA polymerase III subunit L) (RNA polymerase II 7.6 kDa subunit) (RPB7.6) (RPB10 homolog)
Gene: POLR2L

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	33961781, 24981860, 36271492, 19214185
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001054 - RNA polymerase I activity GO:0003677 - DNA binding GO:0003899 - DNA-directed 5'-3' RNA polymerase activity GO:0005654 - nucleoplasm GO:0005736 - RNA polymerase I complex and 1 others more... GO:0008270 - zinc ion binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1720 Hs			1 67
+	Sc
		501320 RPA1_YEAST (3-1719): 0: 1494: 35.97		RPAB5_YEAST (1-67): 1.8e-30: 103: 72.06
+	Hv
		89545 D4GZX6_HALVD (3-1065): 0: 881: 25.19		D4GWX5_HALVD (1-62): 1e-23: 85.8: 41.27
+	Bt
		102293 RPB1_BOVIN (1411-1718): 6.29e-78: 289: 19.24		RPAB5_BOVIN (1-67): 3.73e-35: 114: 100.00
+	Hs
		624853 RPB1_HUMAN (1411-1718): 6.4e-78: 289: 19.24		RPAB5_HUMAN (1-67): 3.73e-35: 114: 100.00
+	Sp
		143457 RPB1_SCHPO (1410-1718): 4.06e-77: 286: 21.78		RPAB5_SCHPO (1-67): 4.78e-33: 109: 71.64
+	Sc
		375277 RPB1_YEAST (1410-1718): 7.44e-71: 266: 21.98		RPAB5_YEAST (1-67): 1.8e-30: 103: 72.06
+	Hs
		156014 RPC1_HUMAN (1525-1718): 1.32e-56: 219: 27.18		RPAB5_HUMAN (1-67): 3.73e-35: 114: 100.00
+	Sc
		375578 RPC1_YEAST (1532-1716): 9.31e-54: 209: 27.42		RPAB5_YEAST (1-67): 1.8e-30: 103: 72.06
+	At
		1228007 NRPD1_ARATH (1585-1716): 1.91e-35: 150: 26.62		NRPBA_ARATH (1-67): 6.99e-34: 111: 80.60
+	Hv
		89546 D4GZX7_HALVD (1168-1337): 7.41e-31: 129: 25.14		D4GWX5_HALVD (1-62): 1e-23: 85.8: 41.27
+	At
		1125370 NRPE1_ARATH (10-99): 6.51e-11: 70: 25.28		NRPBA_ARATH (1-67): 6.99e-34: 111: 80.60