HitPredict

Interactor 1: RPA1 (O95602)
DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (A190) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) (RNA polymerase I 194 kDa subunit) (RPA194)
Gene: POLR1A

Interactor 2: RUVB1 (Q9Y265)
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
Gene: RUVBL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1720 Hs			1 456
+	Mm
		192267 RPA1_MOUSE (1-1720): 0: 1922: 86.05		RUVB1_MOUSE (1-456): 0: 704: 99.78
+	Hs
		317187 RPA1_HUMAN (1-1720): 0: 1954: 100.00		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Mm
		444957 RPB1_MOUSE (1411-1718): 6.08e-78: 289: 19.24		RUVB1_MOUSE (1-456): 0: 704: 99.78
+	Hs
		625106 RPB1_HUMAN (1411-1718): 6.4e-78: 289: 19.24		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Hs
		156083 RPC1_HUMAN (1525-1718): 1.32e-56: 219: 27.18		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Mm
		70955 B2RXC6_MOUSE (1525-1718): 2.55e-56: 218: 27.18		RUVB1_MOUSE (1-456): 0: 704: 99.78
+	Sc
		375494 RPB1_YEAST (1410-1718): 7.44e-71: 266: 21.98		RUVB1_YEAST (1-455): 0: 652: 67.39
+	Sc
		375544 RPB1_YEAST (1410-1718): 7.44e-71: 266: 21.98		RUVB2_YEAST (5-455): 0: 627: 41.72
+	Hs
		156082 RPC1_HUMAN (1525-1718): 1.32e-56: 219: 27.18		RUVB2_HUMAN (2-455): 0: 651: 42.76