HitPredict

Interactor 1: CPSF4 (O95639)
Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and polyadenylation specificity factor 30 kDa subunit) (CPSF 30 kDa subunit) (NS1 effector domain-binding protein 1) (Neb-1) (No arches homolog)
Gene: CPSF4

Interactor 2: SRSF7 (Q16629)
Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)
Gene: SRSF7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~zf-CCCH
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0006397 - mRNA processing GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 269 Hs			1 238
+	Hs
		317824 CPSF4_HUMAN (1-269): 7.46e-105: 307: 100.00		SRSF3_HUMAN (5-154): 2.52e-24: 96.5: 55.33
+	Hs
		1221414 ZC3H3_HUMAN (31-226): 5.83e-38: 143: 25.50		ZCRB1_HUMAN (7-221): 2.04e-28: 108: 22.73
+	Hs
		432803 ZC3H3_HUMAN (31-226): 5.83e-38: 143: 25.50		HNRPC_HUMAN (3-186): 3e-24: 99: 22.58
+	Hs
		1031384 ZC3H3_HUMAN (31-226): 5.83e-38: 143: 25.50		PABP4_HUMAN (1-95): 5.76e-21: 92.9: 27.00
+	Hs
		992837 ZC3H3_HUMAN (31-226): 5.83e-38: 143: 25.50		SRSF1_HUMAN (10-81): 4.51e-21: 90.3: 48.65
+	Hs
		432978 MKRN1_HUMAN (36-257): 4.41e-35: 133: 16.79		HNRPC_HUMAN (3-186): 3e-24: 99: 22.58
+	Hs
		952171 MKRN1_HUMAN (36-257): 4.41e-35: 133: 16.79		SRSF3_HUMAN (5-154): 2.52e-24: 96.5: 55.33
+	Hs
		1221460 ZC3H3_HUMAN (31-226): 5.83e-38: 143: 25.50		PABP3_HUMAN (6-192): 4.81e-18: 84.4: 14.74
+	Hs
		1031488 MKRN1_HUMAN (36-257): 4.41e-35: 133: 16.79		PABP4_HUMAN (1-95): 5.76e-21: 92.9: 27.00
+	Hs
		516728 MKRN1_HUMAN (36-257): 4.41e-35: 133: 16.79		PABP1_HUMAN (6-97): 2.16e-19: 88.2: 22.11
+	Hs
		256485 ZC11A_HUMAN (62-232): 3.95e-30: 120: 16.38		NCBP2_HUMAN (10-114): 8.08e-26: 100: 23.42
+	Hs
		256445 ZC11A_HUMAN (62-232): 3.95e-30: 120: 16.38		HNRPC_HUMAN (3-186): 3e-24: 99: 22.58
+	Hs
		256491 ZC11A_HUMAN (62-232): 3.95e-30: 120: 16.38		SRSF3_HUMAN (5-154): 2.52e-24: 96.5: 55.33
+	Hs
		963580 MKRN1_HUMAN (36-257): 4.41e-35: 133: 16.79		TIAR_HUMAN (5-97): 6.64e-16: 77.8: 25.51
+	Hs
		256453 ZC11A_HUMAN (62-232): 3.95e-30: 120: 16.38		PABP1_HUMAN (6-97): 2.16e-19: 88.2: 22.11
+	Hs
		1084307 ZC3HE_HUMAN (61-186): 1.76e-21: 95.4: 22.37		SRSF7_HUMAN (1-238): 6.03e-28: 108: 100.00
+	Hs
		432772 ZC3HE_HUMAN (61-186): 1.76e-21: 95.4: 22.37		HNRPC_HUMAN (3-186): 3e-24: 99: 22.58
+	Hs
		952003 ZC3HE_HUMAN (61-186): 1.76e-21: 95.4: 22.37		SRSF3_HUMAN (5-154): 2.52e-24: 96.5: 55.33
+	Hs
		1308806 ZC3H4_HUMAN (85-233): 1.1e-19: 90.4: 18.67		RBM4B_HUMAN (12-89): 4.32e-17: 81: 32.05
+	Hs
		1295941 ZC3HA_HUMAN (66-166): 6.41e-20: 90.3: 25.00		RBM4B_HUMAN (12-89): 4.32e-17: 81: 32.05