HitPredict

Interactor 1: CPSF4 (O95639)
Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and polyadenylation specificity factor 30 kDa subunit) (CPSF 30 kDa subunit) (NS1 effector domain-binding protein 1) (Neb-1) (No arches homolog)
Gene: CPSF4

Interactor 2: WDR33 (Q9C0J8)
pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa)
Gene: WDR33

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	29274231, 24981860, 28514442, 33961781, 35177536
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	WD40~zf-CCCH, WD40~zf-CCCH_3
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 269 Hs			1 1336
+	Hs
		64098 CPS4L_HUMAN (1-165): 3.92e-62: 195: 67.27		WDR33_HUMAN (1-1324): 2.65e-176: 561: 96.13
+	Sc
		791182 YTH1_YEAST (1-185): 1.2e-38: 136: 38.34		PFS2_YEAST (49-409): 2.05e-111: 360: 38.80
+	Sp
		1358113 YTH1_SCHPO (65-173): 2.56e-32: 118: 54.96		PFS2_SCHPO (24-287): 2.97e-41: 162: 14.53
+	Hs
		1162363 ZC3HE_HUMAN (61-186): 1.76e-21: 95.4: 22.37		FBXW7_HUMAN (229-428): 7.22e-42: 167: 21.89