HitPredict

Interactor 1: CPSF4 (O95639)
Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and polyadenylation specificity factor 30 kDa subunit) (CPSF 30 kDa subunit) (NS1 effector domain-binding protein 1) (Neb-1) (No arches homolog)
Gene: CPSF4

Interactor 2: CPSF2 (Q9P2I0)
Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) (CPSF 100 kDa subunit)
Gene: CPSF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	33961781, 28514442, 24981860
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 269 Hs			1 782
+	At
		69168 CPSF_ARATH (5-144): 1.62e-30: 121: 35.17		CPSF2_ARATH (1-782): 0: 714: 36.89
+	Hs
		317873 CPSF4_HUMAN (1-269): 7.46e-105: 307: 100.00		CPSF3_HUMAN (2-558): 1.85e-173: 516: 21.28
+	Sp
		251804 YTH1_SCHPO (65-173): 2.56e-32: 118: 54.96		CFT2_SCHPO (22-782): 0: 594: 30.09
+	Hs
		64099 CPS4L_HUMAN (1-165): 3.92e-62: 195: 67.27		CPSF3_HUMAN (2-558): 1.85e-173: 516: 21.28
+	Sc
		985885 YTH1_YEAST (1-185): 1.2e-38: 136: 38.34		CFT2_YEAST (1-780): 7.18e-156: 477: 20.61
+	At
		69150 CPSF_ARATH (5-144): 1.62e-30: 121: 35.17		CPS3B_ARATH (4-567): 3.84e-160: 480: 19.10
+	Sp
		142963 YTH1_SCHPO (65-173): 2.56e-32: 118: 54.96		YSH1_SCHPO (2-540): 3.17e-158: 480: 21.28
+	Sc
		985883 YTH1_YEAST (1-185): 1.2e-38: 136: 38.34		YSH1_YEAST (2-538): 1.74e-145: 447: 21.07
+	Hs
		1135523 ZC3HA_HUMAN (66-166): 6.41e-20: 90.3: 25.00		INT11_HUMAN (5-558): 2.09e-155: 467: 21.67