HitPredict

Interactor 1: NFAC1 (O95644)
Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc)
Gene: NFATC1

Interactor 2: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	16027109
Identification Methods	DNase I footprinting
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:2000573 - positive regulation of DNA biosynthetic process
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 943 Hs			1 233
+	Hs
		352598 NFAC3_HUMAN (24-940): 7e-106: 355: 34.55		TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00
+	Mm
		420392 NFKB1_MOUSE (380-832): 1.07e-103: 347: 15.17		TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81
+	Hs
		352606 NFAC2_HUMAN (37-937): 4e-88: 303: 40.61		TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00
+	Mm
		78126 B5B2U4_MOUSE (24-922): 1.07e-100: 341: 35.47		TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81
+	Hs
		317913 NFAC1_HUMAN (1-943): 4.64e-146: 459: 100.00		CD40L_HUMAN (48-233): 1.16e-45: 154: 24.49
+	Hs
		352617 NFAC4_HUMAN (41-937): 1.43e-80: 282: 32.50		TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00
+	Hs
		352589 TF65_HUMAN (408-939): 5.93e-78: 266: 17.86		TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00
+	Hs
		352584 RELB_HUMAN (317-856): 1.73e-77: 265: 14.46		TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00
+	Hs
		300514 NFAT5_HUMAN (172-923): 2.45e-71: 260: 23.76		TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00
+	Mm
		420398 RELB_MOUSE (390-856): 2.06e-80: 273: 16.08		TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81
+	Mm
		420397 TF65_MOUSE (413-939): 5.69e-78: 266: 17.48		TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81
+	Mm
		420412 NFAT5_MOUSE (172-923): 2.28e-73: 266: 23.72		TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81
+	Hs
		155683 NFAC3_HUMAN (24-940): 7e-106: 355: 34.55		TNF11_HUMAN (52-233): 5.98e-50: 167: 18.14
+	Hs
		669879 REL_HUMAN (419-924): 3.8e-101: 331: 15.34		CD40L_HUMAN (48-233): 1.16e-45: 154: 24.49
+	Hs
		669883 NFAC2_HUMAN (37-937): 4e-88: 303: 40.61		CD40L_HUMAN (48-233): 1.16e-45: 154: 24.49
+	Hs
		815717 MYO15_HUMAN (32-503): 1.11e-19: 97.6: 10.35		TNFL6_HUMAN (20-233): 2.88e-72: 223: 25.46