HitPredict

Interactor 1: NFAC1 (O95644)
Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc)
Gene: NFATC1

Interactor 2: PP2BC (P48454)
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin, testis-specific catalytic subunit) (Calmodulin-dependent calcineurin A subunit gamma isoform)
Gene: PPP3CC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0033173 - calcineurin-NFAT signaling cascade
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 943 Hs			1 512
+	Hs
		317957 NFAC1_HUMAN (1-943): 4.64e-146: 459: 100.00		PP2BA_HUMAN (6-512): 0: 826: 80.59
+	Mm
		930609 Q6P7T9_MOUSE (1-825): 5.52e-122: 392: 86.35		PP2BA_MOUSE (6-512): 0: 824: 80.39
+	Hs
		994078 NFAC2_HUMAN (37-937): 4e-88: 303: 40.61		PP2BA_HUMAN (6-512): 0: 826: 80.59
+	Hs
		819153 NFAC4_HUMAN (41-937): 1.43e-80: 282: 32.50		PP2BC_HUMAN (1-512): 0: 844: 100.00
+	Hs
		994083 NFAC4_HUMAN (41-937): 1.43e-80: 282: 32.50		PP2BA_HUMAN (6-512): 0: 826: 80.59
+	Dm
		819193 NFKB1_DROME (304-706): 1.61e-86: 300: 16.40		PP2B1_DROME (7-481): 0: 721: 70.67
+	Dm
		547617 DORS_DROME (387-702): 3.03e-49: 191: 16.42		PP2B2_DROME (1-503): 0: 759: 73.24
+	Hs
		905877 NFAC2_HUMAN (37-937): 4e-88: 303: 40.61		PP1A_HUMAN (33-333): 8.53e-171: 486: 35.48
+	Hs
		915168 TF65_HUMAN (408-939): 5.93e-78: 266: 17.86		PP2AB_HUMAN (38-334): 4.61e-170: 483: 39.80
+	Hs
		930811 TF65_HUMAN (408-939): 5.93e-78: 266: 17.86		PP2AA_HUMAN (38-334): 3.44e-169: 481: 39.47