HitPredict

Interactor 1: APBB3 (O95704)
Amyloid-beta A4 precursor protein-binding family B member 3 (Protein Fe65-like 2) (Fe65L2)
Gene: APBB3

Interactor 2: APLP1 (P51693)
Amyloid beta precursor like protein 1 (Amyloid beta (A4) precursor-like protein 1) (Amyloid-like protein 1) (APLP) (APLP-1) [Cleaved into: C30]
Gene: APLP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.80	0.774

Property	Details
Experiments	28514442, 10081969, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	APP_amyloid~PID
Common GO terms	-
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 486 Hs			1 650
+	Hs
		319411 APBB3_HUMAN (1-486): 0: 821: 100.00		APLP2_HUMAN (42-648): 0: 822: 35.25
+	Hs
		849943 APBB2_HUMAN (16-486): 0: 718: 40.12		APLP1_HUMAN (1-650): 0: 906: 100.00
+	Hs
		987529 APBB2_HUMAN (16-486): 0: 718: 40.12		APLP2_HUMAN (42-648): 0: 822: 35.25
+	Hs
		120871 APBB1_HUMAN (17-486): 0: 626: 37.40		APLP1_HUMAN (1-650): 0: 906: 100.00
+	Hs
		120897 APBB1_HUMAN (17-486): 0: 626: 37.40		APLP2_HUMAN (42-648): 0: 822: 35.25
+	Hs
		319403 APBB3_HUMAN (1-486): 0: 821: 100.00		A4_HUMAN (41-243): 2.19e-109: 349: 42.16
+	Mm
		517679 APBB3_MOUSE (1-485): 0: 805: 91.75		A4_MOUSE (23-241): 1.64e-115: 364: 42.27
+	Rn
		193495 APBB3_RAT (1-480): 0: 784: 91.04		A4_RAT (23-241): 1.7e-115: 364: 42.27
+	Mm
		517702 APBB2_MOUSE (16-486): 0: 705: 39.53		A4_MOUSE (23-241): 1.64e-115: 364: 42.27
+	Hs
		395373 APBB2_HUMAN (16-486): 0: 718: 40.12		A4_HUMAN (41-243): 2.19e-109: 349: 42.16
+	Rn
		441680 APBB1_RAT (17-486): 0: 637: 37.40		A4_RAT (23-241): 1.7e-115: 364: 42.27
+	Mm
		517713 APBB1_MOUSE (17-486): 0: 626: 37.40		A4_MOUSE (23-241): 1.64e-115: 364: 42.27
+	Hs
		120800 APBB1_HUMAN (17-486): 0: 626: 37.40		A4_HUMAN (41-243): 2.19e-109: 349: 42.16