HitPredict

Interactor 1: HERC2 (O95714)
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)
Gene: HERC2

Interactor 2: PABP1 (P11940)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Gene: PABPC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29511261
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 4834 Hs			1 636
+	Hs
		319819 HERC2_HUMAN (1-4834): 0: 6206: 100.00		PABP4_HUMAN (1-635): 0: 534: 74.69
+	Hs
		319711 HERC2_HUMAN (1-4834): 0: 6206: 100.00		NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33
+	Hs
		516643 ITCH_HUMAN (4308-4794): 3.88e-172: 559: 21.37		PABP1_HUMAN (1-636): 0: 582: 100.00
+	Hs
		125122 WWP2_HUMAN (4317-4794): 2.23e-166: 541: 19.22		PABP1_HUMAN (1-636): 0: 582: 100.00
+	Hs
		125430 WWP2_HUMAN (4317-4794): 2.23e-166: 541: 19.22		PABP4_HUMAN (1-635): 0: 534: 74.69
+	Hs
		125147 WWP2_HUMAN (4317-4794): 2.23e-166: 541: 19.22		NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33
+	Hs
		582506 SMUF1_HUMAN (4321-4794): 2.56e-156: 507: 20.58		NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33
+	Hs
		1126965 SMUF1_HUMAN (4321-4794): 2.56e-156: 507: 20.58		PAP1M_HUMAN (294-387): 4.99e-19: 87.4: 24.74
+	Hs
		582364 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33
+	Hs
		1078048 HERC1_HUMAN (2867-3016): 8.76e-11: 71.4: 12.34		PABP5_HUMAN (6-179): 5.04e-39: 149: 25.26