HitPredict

Interactor 1: HERC2 (O95714)
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)
Gene: HERC2

Interactor 2: UBE2H (P62256)
Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UbcH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H)
Gene: UBE2H

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	38113892
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 4834 Hs			1 183
+	Hs
		319786 HERC2_HUMAN (1-4834): 0: 6206: 100.00		UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73
+	Hs
		319766 HERC2_HUMAN (1-4834): 0: 6206: 100.00		UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43
+	Hs
		319780 HERC2_HUMAN (1-4834): 0: 6206: 100.00		UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05
+	Hs
		1294888 ITCH_HUMAN (4308-4794): 3.88e-172: 559: 21.37		UB2D4_HUMAN (7-150): 2.75e-73: 218: 31.08
+	Hs
		919827 ITCH_HUMAN (4308-4794): 3.88e-172: 559: 21.37		UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73
+	Hs
		849411 ITCH_HUMAN (4308-4794): 3.88e-172: 559: 21.37		UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43
+	Hs
		808078 NEDD4_HUMAN (4323-4795): 7.15e-167: 557: 20.29		UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73
+	Hs
		808052 NEDD4_HUMAN (4323-4795): 7.15e-167: 557: 20.29		UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43
+	Hs
		895882 ITCH_HUMAN (4308-4794): 3.88e-172: 559: 21.37		UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05
+	Hs
		808069 NEDD4_HUMAN (4323-4795): 7.15e-167: 557: 20.29		UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05
+	Hs
		919834 NED4L_HUMAN (4321-4795): 3.82e-167: 547: 19.84		UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73
+	Hs
		849416 NED4L_HUMAN (4321-4795): 3.82e-167: 547: 19.84		UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43
+	Hs
		1282329 ITCH_HUMAN (4308-4794): 3.88e-172: 559: 21.37		UB2E3_HUMAN (5-150): 1.84e-65: 201: 28.00
+	Hs
		1294835 ITCH_HUMAN (4308-4794): 3.88e-172: 559: 21.37		UB2E2_HUMAN (5-150): 1.61e-65: 201: 27.33
+	Hs
		895887 NED4L_HUMAN (4321-4795): 3.82e-167: 547: 19.84		UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05
+	Hs
		851871 ITCH_HUMAN (4308-4794): 3.88e-172: 559: 21.37		UB2E1_HUMAN (5-150): 3.02e-64: 197: 27.33
+	Hs
		808057 NEDD4_HUMAN (4323-4795): 7.15e-167: 557: 20.29		UB2E1_HUMAN (5-150): 3.02e-64: 197: 27.33
+	Hs
		1282332 NED4L_HUMAN (4321-4795): 3.82e-167: 547: 19.84		UB2E3_HUMAN (5-150): 1.84e-65: 201: 28.00
+	Hs
		1297357 NED4L_HUMAN (4321-4795): 3.82e-167: 547: 19.84		UB2E2_HUMAN (5-150): 1.61e-65: 201: 27.33
+	Hs
		851875 NED4L_HUMAN (4321-4795): 3.82e-167: 547: 19.84		UB2E1_HUMAN (5-150): 3.02e-64: 197: 27.33