HitPredict

Interactor 1: HERC2 (O95714)
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)
Gene: HERC2

Interactor 2: PSMD2 (Q13200)
26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2)
Gene: PSMD2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 4834 Hs			1 908
+	Hs
		319982 HERC2_HUMAN (1-4834): 0: 6206: 100.00		PSMD1_HUMAN (59-845): 0: 790: 17.31
+	Hs
		72499 B4DE84_HUMAN (2123-2591): 0: 811: 96.16		PSMD2_HUMAN (1-908): 0: 1290: 100.00
+	Hs
		1027800 SMUF1_HUMAN (4321-4794): 2.56e-156: 507: 20.58		PSMD2_HUMAN (1-908): 0: 1290: 100.00
+	Hs
		1027714 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		PSMD2_HUMAN (1-908): 0: 1290: 100.00
+	Hs
		1027658 HERC3_HUMAN (310-574): 2.63e-42: 173: 16.94		PSMD2_HUMAN (1-908): 0: 1290: 100.00
+	Hs
		1192180 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		PSMD1_HUMAN (59-845): 0: 790: 17.31