HitPredict

Interactor 1: HERC2 (O95714)
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)
Gene: HERC2

Interactor 2: TBB3 (Q13509)
Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III)
Gene: TUBB3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	25476789, 29426014
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 4834 Hs			1 450
+	Hs
		319791 HERC2_HUMAN (1-4834): 0: 6206: 100.00		TBB4B_HUMAN (1-427): 0: 703: 93.91
+	Hs
		319992 HERC2_HUMAN (1-4834): 0: 6206: 100.00		TBB6_HUMAN (1-446): 0: 700: 92.38
+	Hs
		125436 WWP2_HUMAN (4317-4794): 2.23e-166: 541: 19.22		TBB3_HUMAN (1-450): 0: 723: 100.00
+	Hs
		125094 WWP2_HUMAN (4317-4794): 2.23e-166: 541: 19.22		TBB5_HUMAN (1-429): 0: 704: 93.94
+	Hs
		428451 SMUF1_HUMAN (4321-4794): 2.56e-156: 507: 20.58		TBB5_HUMAN (1-429): 0: 704: 93.94
+	Hs
		933985 SMUF1_HUMAN (4321-4794): 2.56e-156: 507: 20.58		TBB4B_HUMAN (1-427): 0: 703: 93.91
+	Dm
		1098200 Q9W325_DROME (4379-4794): 1.23e-144: 461: 23.13		TBB1_DROME (1-429): 0: 702: 93.24
+	Dm
		89887 D5SHR3_DROME (4379-4794): 1.15e-144: 461: 23.13		TBB1_DROME (1-429): 0: 702: 93.24
+	Hs
		428276 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		TBB5_HUMAN (1-429): 0: 704: 93.94
+	Hs
		933869 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		TBB4B_HUMAN (1-427): 0: 703: 93.91
+	Hs
		1046502 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		TBB2A_HUMAN (1-430): 0: 700: 93.49