HitPredict

Interactor 1: HERC2 (O95714)
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)
Gene: HERC2

Interactor 2: MAP7 (Q14244)
Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7)
Gene: MAP7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 4834 Hs			1 749
+	Mm
		57174 HERC2_MOUSE (1-4834): 0: 6208: 95.51		MA7D1_MOUSE (20-661): 6.54e-52: 196: 30.87
+	Hs
		319981 HERC2_HUMAN (1-4834): 0: 6206: 100.00		MA7D2_HUMAN (26-681): 1.97e-39: 157: 24.54
+	Hs
		319873 HERC2_HUMAN (1-4834): 0: 6206: 100.00		CAMP1_HUMAN (71-560): 9.72e-29: 125: 15.53
+	Mm
		949284 HERC2_MOUSE (1-4834): 0: 6208: 95.51		TNIK_MOUSE (31-493): 1.7e-22: 105: 13.52
+	Hs
		319843 HERC2_HUMAN (1-4834): 0: 6206: 100.00		PLEC_HUMAN (430-636): 7.37e-13: 74.9: 20.83
+	Hs
		125500 WWP2_HUMAN (4317-4794): 2.23e-166: 541: 19.22		MA7D1_HUMAN (20-682): 5.64e-49: 187: 30.17
+	Hs
		1078893 ITCH_HUMAN (4308-4794): 3.88e-172: 559: 21.37		ITSN1_HUMAN (212-627): 5.03e-37: 152: 14.29
+	Hs
		808106 NEDD4_HUMAN (4323-4795): 7.15e-167: 557: 20.29		EP300_HUMAN (71-604): 1.01e-24: 113: 14.26
+	Hs
		808315 NEDD4_HUMAN (4323-4795): 7.15e-167: 557: 20.29		TNIK_HUMAN (31-501): 3.32e-24: 111: 14.14
+	Mm
		808345 NEDD4_MOUSE (4338-4795): 5.4e-170: 552: 20.52		TNIK_MOUSE (31-493): 1.7e-22: 105: 13.52
+	Mm
		93268 E9PXB7_MOUSE (4321-4795): 5.25e-169: 547: 19.84		TNIK_MOUSE (31-493): 1.7e-22: 105: 13.52
+	Mm
		949373 NED4L_MOUSE (4321-4795): 7.11e-167: 547: 19.84		TNIK_MOUSE (31-493): 1.7e-22: 105: 13.52
+	Dm
		54898 SUDX_DROME (4313-4791): 1.35e-162: 533: 19.64		A1ZA72_DROME (20-717): 1.17e-19: 97: 11.64
+	Hs
		1336112 SMUF1_HUMAN (4321-4794): 2.56e-156: 507: 20.58		TNIK_HUMAN (31-501): 3.32e-24: 111: 14.14
+	Hs
		719588 NED4L_HUMAN (4321-4795): 3.82e-167: 547: 19.84		MERL_HUMAN (476-620): 3.55e-10: 65.4: 24.66
+	Hs
		125188 WWP2_HUMAN (4317-4794): 2.23e-166: 541: 19.22		MERL_HUMAN (476-620): 3.55e-10: 65.4: 24.66
+	Hs
		1192147 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		CBP_HUMAN (71-604): 3.5e-46: 180: 15.57
+	Hs
		1264807 SMUF2_HUMAN (4316-4794): 1.68e-158: 513: 22.11		TITIN_HUMAN (68-741): 1.24e-11: 70.9: 8.66
+	Mm
		949337 HUWE1_MOUSE (4365-4788): 3.47e-118: 426: 24.00		TNIK_MOUSE (31-493): 1.7e-22: 105: 13.52
+	Hs
		719532 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		MERL_HUMAN (476-620): 3.55e-10: 65.4: 24.66