HitPredict

Interactor 1: HERC2 (O95714)
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)
Gene: HERC2

Interactor 2: WDR59 (Q6PJI9)
GATOR2 complex protein WDR59 (WD repeat-containing protein 59)
Gene: WDR59

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	25476789, 29426014
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 4834 Hs			1 974
+	Hs
		319956 HERC2_HUMAN (1-4834): 0: 6206: 100.00		FBXW7_HUMAN (219-506): 1.23e-21: 102: 12.93
+	Hs
		319979 HERC2_HUMAN (1-4834): 0: 6206: 100.00		WDR24_HUMAN (3-165): 3.25e-20: 98.7: 12.79
+	Hs
		125310 WWP2_HUMAN (4317-4794): 2.23e-166: 541: 19.22		WDR5_HUMAN (180-476): 8.37e-46: 169: 14.38
+	Hs
		125698 WWP2_HUMAN (4317-4794): 2.23e-166: 541: 19.22		WDR33_HUMAN (5-175): 7.31e-37: 152: 12.43
+	Hs
		1083295 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		RBBP7_HUMAN (43-334): 3.53e-61: 216: 20.46
+	Hs
		125681 WWP2_HUMAN (4317-4794): 2.23e-166: 541: 19.22		GRWD1_HUMAN (96-354): 6.12e-21: 99.1: 16.60
+	Hs
		125412 WWP2_HUMAN (4317-4794): 2.23e-166: 541: 19.22		RBBP4_HUMAN (145-377): 1.33e-17: 88.4: 20.39
+	Sc
		765291 RSP5_YEAST (4316-4794): 6.73e-160: 520: 18.52		COPB2_YEAST (5-295): 8.36e-15: 81.3: 9.42
+	Hs
		1223643 HACE1_HUMAN (4274-4788): 1.9e-136: 455: 22.58		GRWD1_HUMAN (96-354): 6.12e-21: 99.1: 16.60
+	Hs
		1192155 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		FBXW7_HUMAN (219-506): 1.23e-21: 102: 12.93
+	Hs
		1192190 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		GRWD1_HUMAN (96-354): 6.12e-21: 99.1: 16.60
+	Hs
		997784 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		RBBP4_HUMAN (145-377): 1.33e-17: 88.4: 20.39
+	At
		794492 UVR8_ARATH (3842-4195): 2.78e-84: 287: 24.53		COP1_ARATH (4-313): 3.44e-26: 117: 17.51
+	Hs
		1281460 HERC5_HUMAN (424-597): 6.72e-11: 71.2: 26.56		FBXW7_HUMAN (219-506): 1.23e-21: 102: 12.93