HitPredict

Interactor 1: HERC2 (O95714)
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)
Gene: HERC2

Interactor 2: RBCC1 (Q8TDY2)
RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200)
Gene: RB1CC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34226595
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 4834 Hs			1 1594
+	Hs
		319994 HERC2_HUMAN (1-4834): 0: 6206: 100.00		CP250_HUMAN (505-1593): 2.27e-40: 166: 10.73
+	Hs
		319864 HERC2_HUMAN (1-4834): 0: 6206: 100.00		GRDN_HUMAN (907-1591): 2.18e-17: 91.1: 10.32
+	Mm
		1118137 HERC2_MOUSE (1-4834): 0: 6208: 95.51		MYH10_MOUSE (1179-1592): 3.09e-15: 84.1: 9.66
+	Hs
		319843 HERC2_HUMAN (1-4834): 0: 6206: 100.00		PLEC_HUMAN (101-713): 3.96e-12: 74.1: 7.02
+	Mm
		1118160 HERC2_MOUSE (1-4834): 0: 6208: 95.51		DYST_MOUSE (159-1538): 4.63e-10: 67.2: 9.49
+	Hs
		319988 HERC2_HUMAN (1-4834): 0: 6206: 100.00		AKAP9_HUMAN (793-1458): 2.62e-09: 64.5: 14.18
+	Mm
		808377 NEDD4_MOUSE (4338-4795): 5.4e-170: 552: 20.52		RBCC1_MOUSE (1-1594): 1.61e-153: 511: 89.08
+	Hs
		1192135 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		RBCC1_HUMAN (1-1594): 9.92e-159: 526: 100.00
+	Hs
		1113845 WWP1_HUMAN (4323-4794): 3.33e-165: 539: 20.88		GRDN_HUMAN (907-1591): 2.18e-17: 91.1: 10.32
+	Hs
		1113852 SMUF1_HUMAN (4321-4794): 2.56e-156: 507: 20.58		GRDN_HUMAN (907-1591): 2.18e-17: 91.1: 10.32
+	Hs
		1192196 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		CP250_HUMAN (505-1593): 2.27e-40: 166: 10.73
+	Hs
		551845 SMUF1_HUMAN (4321-4794): 2.56e-156: 507: 20.58		DESP_HUMAN (899-1502): 4.19e-13: 77.2: 12.32
+	Hs
		724896 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		MYH9_HUMAN (1067-1588): 1.89e-22: 107: 11.48
+	Hs
		1192189 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		AKAP9_HUMAN (793-1458): 2.62e-09: 64.5: 14.18
+	Hs
		148866 HERC1_HUMAN (2867-3016): 8.76e-11: 71.4: 12.34		CTRO_HUMAN (605-1125): 1.59e-12: 75.2: 10.62
+	Hs
		551760 NEK8_HUMAN (4165-4333): 2.8e-09: 65.9: 29.23		DESP_HUMAN (899-1502): 4.19e-13: 77.2: 12.32