HitPredict

Interactor 1: HERC2 (O95714)
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)
Gene: HERC2

Interactor 2: NUDC2 (Q8WVJ2)
NudC domain-containing protein 2
Gene: NUDCD2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	25476789, 31427565, 29426014
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 4834 Hs			1 157
+	Hs
		1192275 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		NUDC_HUMAN (16-142): 2.95e-46: 155: 21.21
+	Hs
		1065047 HERC3_HUMAN (310-574): 2.63e-42: 173: 16.94		NUDC2_HUMAN (1-157): 2.17e-77: 228: 100.00
+	Hs
		307265 RCBT2_HUMAN (603-769): 1.98e-16: 88.6: 35.47		NUDC2_HUMAN (1-157): 2.17e-77: 228: 100.00
+	Hs
		1242532 RCBT1_HUMAN (425-630): 1.33e-14: 82.4: 28.70		NUDC2_HUMAN (1-157): 2.17e-77: 228: 100.00
+	Hs
		1261442 HERC5_HUMAN (424-597): 6.72e-11: 71.2: 26.56		NUDC2_HUMAN (1-157): 2.17e-77: 228: 100.00
+	Hs
		1197675 NEK8_HUMAN (4165-4333): 2.8e-09: 65.9: 29.23		NUDC2_HUMAN (1-157): 2.17e-77: 228: 100.00
+	Hs
		1197690 NEK8_HUMAN (4165-4333): 2.8e-09: 65.9: 29.23		NUDC_HUMAN (16-142): 2.95e-46: 155: 21.21
+	Hs
		1242536 RCBT1_HUMAN (425-630): 1.33e-14: 82.4: 28.70		NUDC1_HUMAN (16-135): 7.3e-34: 126: 20.16
+	Hs
		1197670 NEK8_HUMAN (4165-4333): 2.8e-09: 65.9: 29.23		NUDC3_HUMAN (17-132): 9.89e-29: 109: 21.49