HitPredict

Interactor 1: HERC2 (O95714)
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)
Gene: HERC2

Interactor 2: CC136 (Q96JN2)
Coiled-coil domain-containing protein 136 (Nasopharyngeal carcinoma-associated gene 6 protein)
Gene: CCDC136

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007283 - spermatogenesis
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 4834 Hs			1 1154
+	Mm
		1118137 HERC2_MOUSE (1-4834): 0: 6208: 95.51		MYH10_MOUSE (471-1135): 3.78e-26: 119: 10.95
+	Hs
		319843 HERC2_HUMAN (1-4834): 0: 6206: 100.00		PLEC_HUMAN (213-1096): 6.4e-15: 82.4: 12.25
+	Hs
		1336100 SMUF1_HUMAN (4321-4794): 2.56e-156: 507: 20.58		DAPLE_HUMAN (28-987): 1.43e-26: 120: 13.31
+	Hs
		551845 SMUF1_HUMAN (4321-4794): 2.56e-156: 507: 20.58		DESP_HUMAN (4-548): 1.02e-11: 72: 15.12
+	Hs
		724896 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		MYH9_HUMAN (362-1142): 3.6e-30: 132: 11.84
+	Hs
		551760 NEK8_HUMAN (4165-4333): 2.8e-09: 65.9: 29.23		DESP_HUMAN (4-548): 1.02e-11: 72: 15.12