HitPredict

Interactor 1: HERC2 (O95714)
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)
Gene: HERC2

Interactor 2: DNJC7 (Q99615)
DnaJ homolog subfamily C member 7 (Tetratricopeptide repeat protein 2) (TPR repeat protein 2)
Gene: DNAJC7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	33957083
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ANAPC10~TPR_8, Cyt-b5~DnaJ
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 4834 Hs			1 494
+	Hs
		279267 HERC2_HUMAN (1-4834): 0: 6206: 100.00		DNJB5_HUMAN (380-491): 5.82e-19: 90.1: 43.31
+	Hs
		319931 HERC2_HUMAN (1-4834): 0: 6206: 100.00		DNJB8_HUMAN (381-482): 1.21e-15: 78.2: 44.35
+	Hs
		125007 WWP2_HUMAN (4317-4794): 2.23e-166: 541: 19.22		OGT1_HUMAN (3-401): 1.62e-31: 130: 13.59
+	Hs
		684966 NED4L_HUMAN (4321-4795): 3.82e-167: 547: 19.84		STIP1_HUMAN (4-156): 5.02e-23: 104: 25.49
+	Hs
		175222 SMUF1_HUMAN (4321-4794): 2.56e-156: 507: 20.58		OGT1_HUMAN (3-401): 1.62e-31: 130: 13.59
+	Hs
		1294863 ITCH_HUMAN (4308-4794): 3.88e-172: 559: 21.37		RPAP3_HUMAN (2-223): 2.82e-09: 61.6: 11.92
+	Hs
		808274 NEDD4_HUMAN (4323-4795): 7.15e-167: 557: 20.29		RPAP3_HUMAN (2-223): 2.82e-09: 61.6: 11.92
+	Hs
		125715 WWP2_HUMAN (4317-4794): 2.23e-166: 541: 19.22		RPAP3_HUMAN (2-223): 2.82e-09: 61.6: 11.92
+	Mm
		1186484 HUWE1_MOUSE (4365-4788): 3.47e-118: 426: 24.00		OGT1_MOUSE (3-401): 1.38e-31: 131: 13.59
+	Hs
		175005 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		OGT1_HUMAN (3-401): 1.62e-31: 130: 13.59
+	Ce
		185196 Q9GUP2_CAEEL (4376-4789): 1.61e-116: 421: 23.22		OGT1_CAEEL (6-206): 1.1e-24: 110: 16.42
+	Hs
		684846 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		STIP1_HUMAN (4-156): 5.02e-23: 104: 25.49
+	Hs
		858646 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		PPP5_HUMAN (242-391): 7.28e-09: 60.1: 31.79
+	Hs
		1125826 HERC4_HUMAN (782-937): 3.37e-12: 75.6: 10.69		DNJC7_HUMAN (1-494): 2.58e-85: 273: 100.00
+	Hs
		1305138 HERC5_HUMAN (424-597): 6.72e-11: 71.2: 26.56		DNJC7_HUMAN (1-494): 2.58e-85: 273: 100.00
+	Hs
		1197680 NEK8_HUMAN (4165-4333): 2.8e-09: 65.9: 29.23		DNJC7_HUMAN (1-494): 2.58e-85: 273: 100.00
+	Hs
		684848 NEK8_HUMAN (4165-4333): 2.8e-09: 65.9: 29.23		STIP1_HUMAN (4-156): 5.02e-23: 104: 25.49
+	Hs
		1197683 NEK8_HUMAN (4165-4333): 2.8e-09: 65.9: 29.23		RPAP3_HUMAN (2-223): 2.82e-09: 61.6: 11.92