HitPredict

Interactor 1: HERC2 (O95714)
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)
Gene: HERC2

Interactor 2: AKAP9 (Q99996)
A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao)
Gene: AKAP9

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25476789
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 4834 Hs			1 3907
+	Mm
		1118149 HERC2_MOUSE (1-4834): 0: 6208: 95.51		AKAP9_MOUSE (1-3907): 0: 725: 65.51
+	Hs
		319994 HERC2_HUMAN (1-4834): 0: 6206: 100.00		CP250_HUMAN (2-1330): 1.53e-46: 189: 10.71
+	Hs
		166652 HERC2_HUMAN (1-4834): 0: 6206: 100.00		CE290_HUMAN (2108-3900): 1.69e-42: 175: 10.38
+	Mm
		1118160 HERC2_MOUSE (1-4834): 0: 6208: 95.51		DYST_MOUSE (793-3768): 2.53e-41: 172: 9.74
+	Hs
		319843 HERC2_HUMAN (1-4834): 0: 6206: 100.00		PLEC_HUMAN (2053-3720): 9.98e-35: 150: 11.45
+	Mm
		1118137 HERC2_MOUSE (1-4834): 0: 6208: 95.51		MYH10_MOUSE (1979-2764): 3.47e-16: 88.5: 14.95
+	Hs
		1192189 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		AKAP9_HUMAN (1-3907): 0: 878: 100.00
+	Hs
		1192196 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		CP250_HUMAN (2-1330): 1.53e-46: 189: 10.71
+	Dm
		54898 SUDX_DROME (4313-4791): 1.35e-162: 533: 19.64		A1ZA72_DROME (1714-3696): 9.58e-12: 74.4: 9.91
+	Hs
		551845 SMUF1_HUMAN (4321-4794): 2.56e-156: 507: 20.58		DESP_HUMAN (2135-3311): 1.98e-09: 66.5: 13.94
+	Hs
		1336100 SMUF1_HUMAN (4321-4794): 2.56e-156: 507: 20.58		DAPLE_HUMAN (2137-2753): 8.15e-09: 64.2: 14.04
+	Hs
		724896 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		MYH9_HUMAN (135-781): 3.02e-14: 82.3: 15.29
+	Hs
		317289 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		PCNT_HUMAN (220-863): 6.95e-11: 71.2: 11.28
+	Hs
		148866 HERC1_HUMAN (2867-3016): 8.76e-11: 71.4: 12.34		CTRO_HUMAN (18-648): 1.78e-09: 66.5: 12.83
+	Hs
		551760 NEK8_HUMAN (4165-4333): 2.8e-09: 65.9: 29.23		DESP_HUMAN (2135-3311): 1.98e-09: 66.5: 13.94