HitPredict

Interactor 1: HERC2 (O95714)
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)
Gene: HERC2

Interactor 2: HOOK1 (Q9UJC3)
Protein Hook homolog 1 (h-hook1) (hHK1)
Gene: HOOK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26186194, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 4834 Hs			1 728
+	Mm
		1118137 HERC2_MOUSE (1-4834): 0: 6208: 95.51		MYH10_MOUSE (1-650): 2.89e-29: 127: 11.47
+	Hs
		319864 HERC2_HUMAN (1-4834): 0: 6206: 100.00		GRDN_HUMAN (160-728): 9.47e-25: 113: 14.22
+	Hs
		1113845 WWP1_HUMAN (4323-4794): 3.33e-165: 539: 20.88		GRDN_HUMAN (160-728): 9.47e-25: 113: 14.22
+	Hs
		1113852 SMUF1_HUMAN (4321-4794): 2.56e-156: 507: 20.58		GRDN_HUMAN (160-728): 9.47e-25: 113: 14.22
+	Hs
		1336100 SMUF1_HUMAN (4321-4794): 2.56e-156: 507: 20.58		DAPLE_HUMAN (33-676): 3.69e-18: 91.8: 11.43
+	Hs
		724896 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		MYH9_HUMAN (1-550): 5.58e-23: 107: 13.78
+	Mm
		1186481 HUWE1_MOUSE (4365-4788): 3.47e-118: 426: 24.00		HOOK3_MOUSE (216-727): 7.92e-13: 73.9: 11.17