HitPredict

Interactor 1: CXL14 (O95715)
C-X-C motif chemokine 14 (Chemokine BRAK) (MIP-2G) (Small-inducible cytokine B14)
Gene: CXCL14

Interactor 2: CXCL2 (P19875)
C-X-C motif chemokine 2 (Growth-regulated protein beta) (Gro-beta) (Macrophage inflammatory protein 2-alpha) (MIP2-alpha) [Cleaved into: GRO-beta(5-73) (GRO-beta-T) (Hematopoietic synergistic factor) (HSF) (SB-251353)]
Gene: CXCL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	28381538
Identification Methods	pull down, filter binding
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	IL8~IL8
Common GO terms	GO:0005615 - extracellular space GO:0006935 - chemotaxis GO:0008009 - chemokine activity GO:0061844 - antimicrobial humoral immune response mediated by antimicrobial peptide
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 111 Hs			1 107
+	Hs
		320080 CXL14_HUMAN (1-111): 2.98e-72: 211: 100.00		CXCL7_HUMAN (25-106): 1.12e-27: 99.7: 48.78
+	Hs
		320091 CXL14_HUMAN (1-111): 2.98e-72: 211: 100.00		CXCL5_HUMAN (29-104): 3.05e-26: 95.5: 46.05
+	Hs
		320082 CXL14_HUMAN (1-111): 2.98e-72: 211: 100.00		CXL10_HUMAN (17-102): 3e-22: 84.7: 27.27
+	Hs
		320081 CXL14_HUMAN (1-111): 2.98e-72: 211: 100.00		PLF4_HUMAN (40-103): 4.61e-21: 82: 43.75
+	Hs
		150302 CXL14_HUMAN (1-111): 2.98e-72: 211: 100.00		CXL11_HUMAN (21-103): 8.75e-21: 80.9: 28.24
+	Hs
		320099 CXL14_HUMAN (1-111): 2.98e-72: 211: 100.00		CXCL9_HUMAN (33-99): 2.9e-20: 80.5: 47.06