HitPredict

Interactor 1: ERR2 (O95718)
Steroid hormone receptor ERR2 (ERR beta-2) (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2)
Gene: ESRRB

Interactor 2: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.620

Property	Details
Experiments	26517842, 24189400
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 433 Hs			1 732
+	Hs
		320158 ERR2_HUMAN (1-433): 3.53e-167: 478: 100.00		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		368832 ESR1_HUMAN (9-432): 2.54e-114: 349: 32.90		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		431801 NR1H3_HUMAN (23-432): 2.67e-115: 346: 25.29		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		432122 ESR2_HUMAN (62-433): 1.47e-105: 324: 35.28		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		368839 ESR1_HUMAN (9-432): 2.54e-114: 349: 32.90		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		438124 NR1H3_HUMAN (23-432): 2.67e-115: 346: 25.29		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		437901 NR4A1_HUMAN (15-429): 1.95e-103: 320: 28.64		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		377015 GCR_HUMAN (99-352): 3.14e-47: 174: 38.37		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		414416 PRGR_HUMAN (92-352): 4.95e-46: 172: 32.51		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		538114 RXRB_HUMAN (53-431): 2.41e-118: 357: 31.15		ENPL_HUMAN (14-701): 0: 898: 46.78
+	Hs
		368916 ESR1_HUMAN (9-432): 2.54e-114: 349: 32.90		ENPL_HUMAN (14-701): 0: 898: 46.78
+	Gg
		430819 PRGR_CHICK (86-352): 3e-46: 172: 33.45		HS90B_CHICK (1-732): 0: 1072: 84.04
+	Mm
		415154 GCR_MOUSE (99-352): 9.59e-48: 176: 38.13		HS90B_MOUSE (19-732): 0: 1063: 86.98
+	Hs
		377022 GCR_HUMAN (99-352): 3.14e-47: 174: 38.37		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		414418 PRGR_HUMAN (92-352): 4.95e-46: 172: 32.51		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		538337 ESR2_HUMAN (62-433): 1.47e-105: 324: 35.28		ENPL_HUMAN (14-701): 0: 898: 46.78
+	Hs
		538103 NR4A1_HUMAN (15-429): 1.95e-103: 320: 28.64		ENPL_HUMAN (14-701): 0: 898: 46.78
+	Hs
		377062 GCR_HUMAN (99-352): 3.14e-47: 174: 38.37		ENPL_HUMAN (14-701): 0: 898: 46.78
+	Hs
		1123455 ESR2_HUMAN (62-433): 1.47e-105: 324: 35.28		H90B3_HUMAN (19-732): 0: 728: 65.41