HitPredict

Interactor 1: FGF19 (O95750)
Fibroblast growth factor 19 (FGF-19)
Gene: FGF19

Interactor 2: FGFR4 (P22455)
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)
Gene: FGFR4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.63 1.00 0.799

The method score is based on:

Property Details
Experiments 10525310, 19706524
Identification Methods pull down, affinity chromatography technology, solid phase assay
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains FGF~I-set, FGF~Ig_3
Common GO terms GO:0005576 - extracellular region
GO:0008284 - positive regulation of cell population proliferation
GO:0008543 - fibroblast growth factor receptor signaling pathway
GO:0010628 - positive regulation of gene expression
GO:0070374 - positive regulation of ERK1 and ERK2 cascade
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 216
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024